Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease
S Duty, P Jenner - British journal of pharmacology, 2011 - Wiley Online Library
Animal models of Parkinson's disease (PD) have proved highly effective in the discovery of
novel treatments for motor symptoms of PD and in the search for clues to the underlying …
novel treatments for motor symptoms of PD and in the search for clues to the underlying …
What genetics tells us about the causes and mechanisms of Parkinson's disease
O Corti, S Lesage, A Brice - Physiological reviews, 2011 - journals.physiology.org
Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …
Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death
Inclusions composed of α-synuclein (α-syn), ie, Lewy bodies (LBs) and Lewy neurites (LNs),
define synucleinopathies including Parkinson's disease (PD) and dementia with Lewy …
define synucleinopathies including Parkinson's disease (PD) and dementia with Lewy …
LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress
Studies of Parkinson's disease (PD) have been hindered by lack of access to affected
human dopaminergic (DA) neurons. Here, we report generation of induced pluripotent stem …
human dopaminergic (DA) neurons. Here, we report generation of induced pluripotent stem …
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders
Introduction• ER stress and the UPR‐The IRE1 axis: non‐conventional splicing of XBP1
mRNA‐The PERK axis: attenuation of translation‐The ATF6 axis: regulated proteolytic …
mRNA‐The PERK axis: attenuation of translation‐The ATF6 axis: regulated proteolytic …
SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress
Parkinson's disease (PD) is an incurable age-related neurodegenerative disorder affecting
both the central and peripheral nervous systems. Although common, the etiology of PD …
both the central and peripheral nervous systems. Although common, the etiology of PD …
The role of alpha-synuclein in neurotransmission and synaptic plasticity
F Cheng, G Vivacqua, S Yu - Journal of chemical neuroanatomy, 2011 - Elsevier
Alpha-synuclein (α-syn), a synaptic protein richly expressed in the central nervous system,
has been implicated in several neurodegenerative diseases, such as Alzheimer's disease …
has been implicated in several neurodegenerative diseases, such as Alzheimer's disease …
Limitations of animal models of Parkinson′ s disease
JA Potashkin, SR Blume, NK Runkle - Parkinson's disease, 2011 - Wiley Online Library
Most cases of Parkinson′ s disease (PD) are sporadic. When choosing an animal model for
idiopathic PD, one must consider the extent of similarity or divergence between the …
idiopathic PD, one must consider the extent of similarity or divergence between the …
Phenylbutyrate up-regulates the DJ-1 protein and protects neurons in cell culture and in animal models of Parkinson disease
W Zhou, K Bercury, J Cummiskey, N Luong… - Journal of Biological …, 2011 - ASBMB
Parkinson disease is caused by the death of midbrain dopamine neurons from oxidative
stress, abnormal protein aggregation, and genetic predisposition. In 2003, Bonifati et al.(23) …
stress, abnormal protein aggregation, and genetic predisposition. In 2003, Bonifati et al.(23) …
Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease
I Ferrer, A Martinez, R Blanco, E Dalfó… - Journal of neural …, 2011 - Springer
Parkinson disease (PD) is no longer considered a complex motor disorder characterized by
parkinsonism but rather a systemic disease with variegated non-motor deficits and …
parkinsonism but rather a systemic disease with variegated non-motor deficits and …