Tandem mass spectrometry strategies for phosphoproteome analysis
AM Palumbo, SA Smith, CL Kalcic… - Mass spectrometry …, 2011 - Wiley Online Library
Protein phosphorylation is involved in nearly all essential biochemical pathways and the
deregulation of phosphorylation events has been associated with the onset of numerous …
deregulation of phosphorylation events has been associated with the onset of numerous …
Fraternal twins: Swiprosin-1/EFhd2 and Swiprosin-2/EFhd1, two homologous EF-hand containing calcium binding adaptor proteins with distinct functions
Abstract Changes in the intracellular calcium concentration govern cytoskeletal
rearrangement, mitosis, apoptosis, transcriptional regulation or synaptic transmission …
rearrangement, mitosis, apoptosis, transcriptional regulation or synaptic transmission …
Phosphoproteome analysis reveals regulatory sites in major pathways of cardiac mitochondria
N Deng, J Zhang, C Zong, Y Wang, H Lu… - Molecular & Cellular …, 2011 - ASBMB
Mitochondrial functions are dynamically regulated in the heart. In particular, protein
phosphorylation has been shown to be a key mechanism modulating mitochondrial function …
phosphorylation has been shown to be a key mechanism modulating mitochondrial function …
TRPM4 enhances cell proliferation through up‐regulation of the β‐catenin signaling pathway
Altered expression of some members of the TRP ion channel superfamily has been
associated with the development of pathologies like cancer. In particular, TRPM4 levels are …
associated with the development of pathologies like cancer. In particular, TRPM4 levels are …
Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1)
Background Our understanding of signal transduction networks in the physiological context
of an organism remains limited, partly due to the technical challenge of identifying …
of an organism remains limited, partly due to the technical challenge of identifying …
Status and prospects for discovery and verification of new biomarkers of cardiovascular disease by proteomics
Despite unmet needs for cardiovascular biomarkers, few new protein markers have been
approved by the US Food and Drug Administration for the diagnosis or screening of …
approved by the US Food and Drug Administration for the diagnosis or screening of …
Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4
Y Akimoto, Y Miura, T Toda, MA Wolfert, L Wells… - Clinical proteomics, 2011 - Springer
Purpose The objective of the present study is to identify proteins that change in the extent of
the modification with O-linked N-acetylglucosamine (O-GlcNAcylation) in the kidney from …
the modification with O-linked N-acetylglucosamine (O-GlcNAcylation) in the kidney from …
Discovery of protein phosphorylation motifs through exploratory data analysis
Background The need for efficient algorithms to uncover biologically relevant
phosphorylation motifs has become very important with rapid expansion of the proteomic …
phosphorylation motifs has become very important with rapid expansion of the proteomic …
Investigation of POPX2 phosphatase functions by comparative phosphoproteomic analysis
Identifying the substrates and biochemical pathway regulated by phosphatases has always
been more challenging than finding those regulated by kinases. Here, we report the use of …
been more challenging than finding those regulated by kinases. Here, we report the use of …
Identification of phosphoproteins and their impact as biomarkers in cancer therapeutics
SM Frawley Cass, JJ Tepe - Current Signal Transduction …, 2011 - ingentaconnect.com
Many cellular processes are regulated by the reversible reaction of protein phosphorylation
on serine, threonine and tyrosine residues. Deregulation of the signal transduction cascade …
on serine, threonine and tyrosine residues. Deregulation of the signal transduction cascade …