From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications
SM Hattangadi, P Wong, L Zhang… - Blood, The Journal …, 2011 - ashpublications.org
This article reviews the regulation of production of RBCs at several levels. We focus on the
regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids …
regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids …
Histone modification: cause or cog?
S Henikoff, A Shilatifard - Trends in Genetics, 2011 - cell.com
Histone modifications are key components of chromatin packaging but whether they
constitute a 'code'has been contested. We believe that the central issue is causality: are …
constitute a 'code'has been contested. We believe that the central issue is causality: are …
[HTML][HTML] Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution
Thousands of long intervening noncoding RNAs (lincRNAs) have been identified in
mammals. To better understand the evolution and functions of these enigmatic RNAs, we …
mammals. To better understand the evolution and functions of these enigmatic RNAs, we …
The diverse functions of Dot1 and H3K79 methylation
DOT1 (disruptor of telomeric silencing; also called Kmt4) was initially discovered in budding
yeast in a genetic screen for genes whose deletion confers defects in telomeric silencing …
yeast in a genetic screen for genes whose deletion confers defects in telomeric silencing …
DOT1L, the H3K79 methyltransferase, is required for MLL-AF9–mediated leukemogenesis
Chromosomal translocations of the mixed lineage leukemia (MLL) gene are a common
cause of acute leukemias. The oncogenic function of MLL fusion proteins is, in part …
cause of acute leukemias. The oncogenic function of MLL fusion proteins is, in part …
Histone modifications in transcriptional activation during plant development
In eukaryotic cell nuclei, chromatin states dictated by different combinations of post-
translational modifications of histones, such as acetylation, methylation and …
translational modifications of histones, such as acetylation, methylation and …
Vertebrate intestinal endoderm development
JR Spence, R Lauf, NF Shroyer - Developmental dynamics, 2011 - Wiley Online Library
The endoderm gives rise to the lining of the esophagus, stomach and intestines, as well as
associated organs. To generate a functional intestine, a series of highly orchestrated …
associated organs. To generate a functional intestine, a series of highly orchestrated …
Human polymerase-associated factor complex (PAFc) connects the super elongation complex (SEC) to RNA polymerase II on chromatin
The Super Elongation Complex (SEC), containing transcription elongation
activators/coactivators P-TEFb, ELL2, AFF4/1, ENL, and AF9, is recruited by HIV-1 Tat and …
activators/coactivators P-TEFb, ELL2, AFF4/1, ENL, and AF9, is recruited by HIV-1 Tat and …
H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation
B Guillemette, P Drogaris, HHS Lin, H Armstrong… - PLoS …, 2011 - journals.plos.org
Methylation of histone H3 lysine 4 (H3K4me) is an evolutionarily conserved modification
whose role in the regulation of gene expression has been extensively studied. In contrast …
whose role in the regulation of gene expression has been extensively studied. In contrast …
Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36
Several lines of recent evidence support a role for chromatin in splicing regulation. Here, we
show that splicing can also contribute to histone modification, which implies bidirectional …
show that splicing can also contribute to histone modification, which implies bidirectional …