Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder. The study of
diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous …

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is known to be
associated with polyclonal B-cell hyperreactivity. The underlying causes of the diffuse B-cell …

Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown origin affecting
virtually all organ systems. Beyond genetic and environmental factors, cytokine imbalances …

Several clinical studies have demonstrated that the humanized anti‐interleukin‐6 (IL‐6)
receptor antibody tocilizumab (TCZ) improves clinical symptoms and prevents progression …

Chronic fatigue is a common, poorly understood and disabling phenomenon in many
diseases. We aim to provide an overview of fatigue in chronic autoimmune and inflammatory …

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with significant
clinical heterogeneity. Recent advances in our understanding of the genetic, molecular, and …

Interleukin (IL)-6 is a cytokine with multiple biological activities. It contributes to host defense
against pathogens, whereas accelerated production of IL-6 plays a significant pathological …

The pathogenesis of systemic lupus erythematosus (SLE) is complex, and the resulting
disease manifestations are heterogeneous. Cytokine dysregulation is pervasive, and their …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is characterized
by a defect in immune tolerance and exacerbated by both the innate and adaptive arms of …

Observations of familial aggregation (λs= 8–29) and a 40% identical twin concordance rate
prompted recent work towards a comprehensive genetic analysis of systemic lupus …