Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms.

GE Miller, E Chen, KJ Parker - Psychological bulletin, 2011 - psycnet.apa.org
Among people exposed to major psychological stressors in early life, there are elevated
rates of morbidity and mortality from chronic diseases of aging. The most compelling data …

Epigenetic modifications: basic mechanisms and role in cardiovascular disease

DE Handy, R Castro, J Loscalzo - Circulation, 2011 - Am Heart Assoc
The term epigenetics was first used to refer to the complex interactions between the genome
and the environment that are involved in development and differentiation in higher …

The human connectome: a complex network

O Sporns - Annals of the new York Academy of Sciences, 2011 - Wiley Online Library
The human brain is a complex network. An important first step toward understanding the
function of such a network is to map its elements and connections, to create a …

Epigenetic predictor of age

S Bocklandt, W Lin, ME Sehl, FJ Sánchez… - PloS one, 2011 - journals.plos.org
From the moment of conception, we begin to age. A decay of cellular structures, gene
regulation, and DNA sequence ages cells and organisms. DNA methylation patterns change …

Transcriptional and epigenetic mechanisms of addiction

AJ Robison, EJ Nestler - Nature reviews neuroscience, 2011 - nature.com
Investigations of long-term changes in brain structure and function that accompany chronic
exposure to drugs of abuse suggest that alterations in gene regulation contribute …

Folic acid food fortification—its history, effect, concerns, and future directions

KS Crider, LB Bailey, RJ Berry - Nutrients, 2011 - mdpi.com
Periconceptional intake of folic acid is known to reduce a woman's risk of having an infant
affected by a neural tube birth defect (NTD). National programs to mandate fortification of …

Child health, developmental plasticity, and epigenetic programming

Z Hochberg, R Feil, M Constancia, M Fraga… - Endocrine …, 2011 - academic.oup.com
Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

Epigenome-wide association studies for common human diseases

VK Rakyan, TA Down, DJ Balding, S Beck - Nature Reviews Genetics, 2011 - nature.com
Despite the success of genome-wide association studies (GWASs) in identifying loci
associated with common diseases, a substantial proportion of the causality remains …

Natural immunity: biodiversity loss and inflammatory diseases are two global megatrends that might be related

L Von Hertzen, I Hanski, T Haahtela - EMBO reports, 2011 - embopress.org
Natural immunity: Biodiversity loss and inflammatory diseases are two global megatrends that
might be related: EMBO reports: Vol 12, No 11 Skip to Article Content Skip to Article Information …

Epigenetics and the origins of paternal effects

JP Curley, R Mashoodh, FA Champagne - Hormones and behavior, 2011 - Elsevier
Though there are multiple routes through which parents can influence their offspring, recent
studies of environmentally induced epigenetic variation have highlighted the role of non …