Human-made information relay systems invariably incorporate central regulatory
components, which are mirrored in biological systems by dense feedback and feedforward …

Primary response genes (PRGs) are a set of genes that are induced in response to both cell-
extrinsic and cell-intrinsic signals and do not require de novo protein synthesis for their …

Transcriptional responses to extracellular stimuli involve tuning the rates of transcript
production and degradation. Here, we show that the time‐dependent profiles of these rates …

Epidermal growth factor receptors (EGFR) contribute to colonic tumorigenesis in
experimental models of colon cancer. We previously showed that EGFR was also required …

Transcriptome dynamics is governed by two opposing processes, mRNA production and
degradation. Recent studies found that changes in these processes are frequently …

Gene expression comprises multiple stages, from transcription to protein degradation.
Although much is known about the regulation of each stage separately, an understanding of …

A limited set of cell–cell signaling pathways presides over the vast majority of animal
developmental events. The typical raison d'etre for signal transduction is to control the …

Time to freezing tumor tissue for RNA expression analysis will always vary to some extent.
To evaluate the effect of ischemia time, tumor tissue from ten breast cancer patients was …

Hepatocyte growth factor (HGF) is a multifunctional molecule that acts as mitogen, motogen,
and/or morphogen in a variety of cells. MET, a specific receptor tyrosine kinase for HGF, is …

Abstract Background Epidermal Growth Factor (EGF) is a key regulatory growth factor
activating many processes relevant to normal development and disease, affecting cell …