Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease
N Itoh, DM Ornitz - The Journal of Biochemistry, 2011 - academic.oup.com
Fibroblast growth factors (FGFs) are a family of structurally related polypeptides that are
essential for embryonic development and that function postnatally as homoeostatic factors …
essential for embryonic development and that function postnatally as homoeostatic factors …
Phosphate toxicity: new insights into an old problem
MS Razzaque - Clinical science, 2011 - portlandpress.com
Phosphorus is an essential nutrient required for critical biological reactions that maintain the
normal homoeostatic control of the cell. This element is an important component of different …
normal homoeostatic control of the cell. This element is an important component of different …
FGF23 induces left ventricular hypertrophy
Chronic kidney disease (CKD) is a public health epidemic that increases risk of death due to
cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of …
cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of …
Klotho inhibits transforming growth factor-β1 (TGF-β1) signaling and suppresses renal fibrosis and cancer metastasis in mice
Fibrosis is a pathological process characterized by infiltration and proliferation of
mesenchymal cells in interstitial space. A substantial portion of these cells is derived from …
mesenchymal cells in interstitial space. A substantial portion of these cells is derived from …
FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway
Regulation of hepatic carbohydrate homeostasis is crucial for maintaining energy balance in
the face of fluctuating nutrient availability. Here, we show that the hormone fibroblast growth …
the face of fluctuating nutrient availability. Here, we show that the hormone fibroblast growth …
Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21
Abstract Fibroblast growth factor-21 (FGF21) is a pleiotropic protein involved in glucose, lipid
metabolism and energy homeostasis, with main tissues of expression being the liver and …
metabolism and energy homeostasis, with main tissues of expression being the liver and …
Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity
FL Mashili, RL Austin, AS Deshmukh… - Diabetes/metabolism …, 2011 - Wiley Online Library
Background Fibroblast growth factor (FGF) 21, a novel member of the FGF family, plays a
role in a variety of endocrine functions, including regulation of glucose and lipid metabolism …
role in a variety of endocrine functions, including regulation of glucose and lipid metabolism …
Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes
Fibroblast growth factor 21 (FGF21) is a liver-secreted endocrine factor with multiple
beneficial effects on obesity-related disorders. It enhances glucose uptake by inducing the …
beneficial effects on obesity-related disorders. It enhances glucose uptake by inducing the …
Nrf2 represses FGF21 during long-term high-fat diet–induced obesity in mice
DV Chartoumpekis, PG Ziros, AI Psyrogiannis… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Obesity is characterized by chronic oxidative stress. Fibroblast growth factor 21
(FGF21) has recently been identified as a novel hormone that regulates metabolism. NFE2 …
(FGF21) has recently been identified as a novel hormone that regulates metabolism. NFE2 …
[HTML][HTML] Klotho and the aging process
M Kuro-o - The Korean journal of internal medicine, 2011 - ncbi.nlm.nih.gov
The klotho gene was originally identified as a putative age-suppressing gene in mice that
extends life span when overexpressed. It induces complex phenotypes resembling human …
extends life span when overexpressed. It induces complex phenotypes resembling human …