Over one hundred years ago, Sir Charles Sherrington described a population of spinal cord
interneurons (INs) that connect multiple spinal cord segments and participate in complex or …

Given the importance of accurately and reliably assessing disability in future clinical trials,
which will test therapeutic strategies in acute spinal cord injury (SCI), we sought to appraise …

Object Many experimental studies on spinal cord injuries (SCIs) support behavioral
improvement after Schwann cell treatment. This study was conducted to evaluate safety …

One of the challenges in treating central nervous system (CNS) disorders with biomolecules
is achieving local delivery while minimizing invasiveness. For the treatment of stroke …

Spinal cord injuries (SCI) can result in devastating paralysis, for which there is currently no
robustly efficacious neuroprotective/neuroregenerative treatment. When the spinal cord is …

The past three decades have seen an explosion of research interest in spinal cord injury
(SCI) and the development of hundreds of potential therapies that have demonstrated some …

Zebrafish possess a robust, innate CNS regenerative ability. Combined with their genetic
tractability and vertebrate CNS architecture, this ability makes zebrafish an attractive model …

Despite numerous studies reporting some measures of efficacy in the animal literature, there
are currently no effective therapies for the treatment of traumatic spinal cord injuries (SCI) in …

One of the major challenges in management of spinal cord injury (SCI) is that the
assessment of injury severity is often imprecise. Identification of reliable, easily quantifiable …

Introduction: Macrophage activation is a hallmark of spinal cord injury (SCI) pathology. CNS
macrophages, derived from resident microglia and blood monocytes, are ubiquitous …