Presynaptic nerve terminals release neurotransmitters by synaptic vesicle exocytosis.
Membrane fusion mediating synaptic exocytosis and other intracellular membrane traffic is …

Synapses exhibit several forms of short-term plasticity that play a multitude of computational
roles. Short-term depression suppresses neurotransmitter release for hundreds of …

At a synapse, the presynaptic active zone mediates synaptic vesicle exocytosis. RIM
proteins are active zone scaffolding molecules that—among others—mediate vesicle …

N-terminal targeting signals (presequences) direct proteins across the TOM complex in the
outer mitochondrial membrane and the TIM23 complex in the inner mitochondrial …

Regulated neurotransmitter secretion depends on Ca 2+ sensors, C2 domain proteins that
associate with phospholipids and soluble N-ethylmaleimide-sensitive fusion attachment …

High-frequency stimulation leads to a transient increase in the amplitude of evoked synaptic
transmission that is known as posttetanic potentiation (PTP). Here we examine the roles of …

J. Neurochem.(2011) 118, 695–713. Abstract In recent years, substantial progress has been
made towards an understanding of the physiological function of EF‐hand calcium sensor …

Long-lasting forms of synaptic plasticity involve modification of presynaptic strength in many
brain regions. Although a presynaptic site for expression is well established, the detailed …

Inner hair cells (IHCs) in the mammalian cochlea are able to continuously release
neurotransmitter in the presence of constant stimuli. Nonetheless, strong synaptic …

Rare human primary immunodeficiency disorders with extreme susceptibility to infections in
infancy have provided important insights into immune function. Increasingly, however …