Identification of a low–molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice
The neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-
related kinase B (TrkB) have emerged as key mediators in the pathophysiology of several …
related kinase B (TrkB) have emerged as key mediators in the pathophysiology of several …
Antagonism of nerve growth factor-TrkA signaling and the relief of pain
Nerve growth factor (NGF) was originally discovered as a neurotrophic factor essential for
the survival of sensory and sympathetic neurons during development. However, in the adult …
the survival of sensory and sympathetic neurons during development. However, in the adult …
Role of neurotrophins in neuropathic pain
D Siniscalco, C Giordano, F Rossi… - Current …, 2011 - ingentaconnect.com
Neurotrophins (NTs) belong to a family of structurally and functionally related proteins, they
are the subsets of neurotrophic factors. Neurotrophins are responsible for diverse actions in …
are the subsets of neurotrophic factors. Neurotrophins are responsible for diverse actions in …
Peptide mimetics of neurotrophins and their receptors
SD Skaper - Current pharmaceutical design, 2011 - ingentaconnect.com
Neurotrophic factors were originally identified based on their ability to prevent naturally
occurring cell death in the developing nervous system. Many of these proteins also promote …
occurring cell death in the developing nervous system. Many of these proteins also promote …
The Inorganic Perspective of Nerve Growth Factor: Interactions of Cu2+ and Zn2+ with the N‐Terminus Fragment of Nerve Growth Factor Encompassing the …
There is a significant overlap between brain areas with Zn2+ and Cu2+ pathological dys‐
homeostasis and those in which the nerve growth factor (NGF) performs its biological role …
homeostasis and those in which the nerve growth factor (NGF) performs its biological role …
Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor
G Cirillo, MR Bianco, AM Colangelo, C Cavaliere… - Neurobiology of …, 2011 - Elsevier
Reactive gliosis has been implicated in both inflammatory and neurodegenerative diseases.
However, mechanisms by which astrocytic activation affects synaptic efficacy have been …
However, mechanisms by which astrocytic activation affects synaptic efficacy have been …
A local anesthetic, ropivacaine, suppresses activated microglia via a nerve growth factor-dependent mechanism and astrocytes via a nerve growth factor-independent …
S Toda, A Sakai, Y Ikeda, A Sakamoto… - Molecular …, 2011 - journals.sagepub.com
Background: Local anesthetics alleviate neuropathic pain in some cases in clinical practice,
and exhibit longer durations of action than those predicted on the basis of the …
and exhibit longer durations of action than those predicted on the basis of the …
Neurotrophic activity of DA-9801, a mixture extract of Dioscorea japonica Thunb. and Dioscorea nipponica Makino, in vitro
N Kim, SH Kim, YJ Kim, JK Kim, MK Nam… - Journal of …, 2011 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Dioscorea japonica Thunb. has been
traditionally used to treat polyuria and diabetes in Korea. AIM OF THE STUDY: We …
traditionally used to treat polyuria and diabetes in Korea. AIM OF THE STUDY: We …
In Vitro Study of Neuroprotective Properties of GK-2, a New Original Nerve Growth Factor Mimetic
TA Antipova, TA Gudasheva, SB Seredenin - Bulletin of experimental …, 2011 - Springer
New nerve growth factor (NGF) mimetic GK-2, a substituted dimeric dipeptide, in a
concentration of up to 10− 9 M produced a protective effect on the culture of immortalized …
concentration of up to 10− 9 M produced a protective effect on the culture of immortalized …
Cross‐talk between cell cycle induction and mitochondrial dysfunction during oxidative stress and nerve growth factor withdrawal in differentiated PC12 cells
MR Bianco, M Berbenni, F Amara… - Journal of …, 2011 - Wiley Online Library
Neuronal death has been reported to involve mitochondrial dysfunction and cell cycle
reentry. In this report, we used Nerve Growth Factor (NGF)‐differentiated PC12 cells to …
reentry. In this report, we used Nerve Growth Factor (NGF)‐differentiated PC12 cells to …