Type 2 diabetes is characterized by a two-to fourfold increased risk of cardiovascular
disease. This is generally attributed to the adverse effects of hyperglycemia and oxidative …

Neuropathy is the most common complication of diabetes. As a consequence of
longstanding hyperglycemia, a downstream metabolic cascade leads to peripheral nerve …

Haematopoietic stem cells (HSCs) are multipotent, self-renewing progenitors that generate
all mature blood cells. HSC function is tightly controlled to maintain haematopoietic …

Bone-marrow-derived EPCs (endothelial progenitor cells) play an integral role in the
regulation and protection of the endothelium, as well as new vessel formation. Peripheral …

Hypertension is the single most important risk factor for cardiovascular disease and, thus,
remains a global public health challenge. Significant progress has been made during the …

Rationale: Acquisition of a procalcific phenotype by resident or circulating cells is important
for calcification of atherosclerotic plaques, which is common in diabetes. Objective: We aim …

Retinal ischaemic disorders such as diabetic retinopathy and retinal vein occlusion are
common. The hypoxia-related stimuli from oxygen-deprived neural and glial networks can …

Stroke induces a systemic response that involves rapid activation of inflammatory cascades,
followed later by immunodepression. Experimental stroke-induced responses in the bone …

Aims/hypothesis Bone marrow (BM)-derived endothelial progenitor cells (EPC) promote
tissue healing and angiogenesis, whereas altered EPC biology may favour diabetic …

Regenerative cardiovascular medicine is the frontline of 21st-century health care. Cell
therapy trials using bone marrow progenitor cells documented that the approach is feasible …