The discovery of methods to convert somatic cells into induced pluripotent stem cells
(iPSCs) through expression of a small combination of transcription factors has raised the …

In this review, we describe the recent advances in the understanding of the role of
microRNAs in idiopathic pulmonary fibrosis (IPF), a chronic progressive and lethal fibrotic …

Induced pluripotent stem cells (iPSCs) offer immense potential for regenerative medicine
and studies of disease and development. Somatic cell reprogramming involves epigenomic …

Defined transcription factors can induce epigenetic reprogramming of adult mammalian cells
into induced pluripotent stem cells. Although DNA factors are integrated during some …

Background Human pluripotent stem cells have the ability to generate all cell types present
in the adult organism, therefore harboring great potential for the in vitro study of …

Tumor heterogeneity is a major barrier to effective cancer diagnosis and treatment. We
recently identified cancer-specific differentially DNA-methylated regions (cDMRs) in colon …

Tissue specific patterns of methylated cytosine residues vary with age, can be altered by
environmental factors, and are often abnormal in human disease yet the cellular …

DNA methylation at the 5 position of cytosine (5mC) in the mammalian genome is a key
epigenetic event critical for various cellular processes. The ten-eleven translocation (Tet) …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare and fatal human premature ageing
disease,,,,, characterized by premature arteriosclerosis and degeneration of vascular …

Human induced pluripotent stem (iPS) cells are remarkably similar to embryonic stem (ES)
cells, but recent reports indicate that there may be important differences between them. We …