The publication of the psychomotor stimulant theory of addiction in 1987 and the finding that
addictive drugs increase dopamine concentrations in the rat mesolimbic system in 1988 …

Although the critical role for epigenetic mechanisms in development and cell differentiation
has long been appreciated, recent evidence reveals that these mechanisms are also …

Over the past several years, drug addiction has increasingly been accepted to be a disease
of the brain as opposed to simply being due to a lack of willpower or personality flaw …

Dopamine (DA) transmission is deeply affected by drugs of abuse, and alterations in DA
function are involved in the various phases of drug addiction and potentially exploitable …

Drug‐induced alterations in gene expression throughout the reward circuitry of the brain are
likely components of the persistence of the drug‐addicted state. Recent studies examining …

Modulating glutamatergic neurotransmission induces alterations in conscious experience
that mimic the symptoms of early psychotic illness. We review studies that use intravenous …

Immediate-early genes have important roles in processes such as brain development,
learning, and responses to drug abuse. Further, immediate-early genes play an essential …

Although the term 'epigenetics' was coined nearly seventy years ago, its critical function in
memory processing by the adult CNS has only recently been appreciated. The hypothesis …

The use of addictive drugs can have profound short-and long-term consequences on social
behaviors. Similarly, social experiences and the presence or absence of social attachments …

We studied the long-term influence of maternal separation (MS) on periadolescent behavior,
adult amphetamine (AMPH) sensitization, and structural plasticity in the corticolimbic regions …