Until recently, most research efforts aimed at developing anti-cancer tools were focusing on
small molecules. Alternative compounds are now being increasingly assessed for their …

Cell death inhibition is a very successful strategy that cancer cells employ to combat the
immune system and various anticancer therapies. Inhibitor of apoptosis (IAP) proteins …

US7932382B2 - Conformationally constrained Smac mimetics and the uses thereof - Google
Patents US7932382B2 - Conformationally constrained Smac mimetics and the uses thereof …

A great leap for an amino acid is enabled by a DNA‐triggered reaction which involves the
transfer of an aminoacyl group from a donating thioester‐linked PNA–peptide hybrid to a …

Apoptosis is an essential process for embryonic and lymphocyte development, immune
system modulation and tissue homeostasis. Defects in apoptotic signaling often lead to …

Pro-apoptotic proteins from the reaper, hid, grim (RHG) family are primary regulators of
programmed cell death in Drosophila due to their antagonistic effect on inhibitor of apoptosis …

We present a method which allows for the translation of nucleic acid information into the
output of molecules that interfere with disease-related protein–protein interactions. The …

Apoptotic induction mechanisms are of crucial importance for the general homeostasis of
multicellular organisms. In cancer the apoptotic pathways are downregulated, which, at least …

Publisher Summary This chapter focuses on the discovery and development of Smac
mimetics—small-molecule antagonists of the inhibitor of apoptosis proteins. Apoptosis, or …

Ein großer Schritt für eine Aminosäure wird durch eine DNA‐gesteuerte Reaktion
ermöglicht. Dabei findet der Transfer einer Aminoacylgruppe von einem übertragenden …