The activity-regulated cytoskeletal (Arc) gene encodes a protein that is critical for memory
consolidation. Arc is one of the most tightly regulated molecules known: neuronal activity …

Long lasting forms of synaptic plasticity and long-term memory formation require new mRNA
and protein synthesis. While activity-dependent expression of immediate-early genes has …

Optical methods for viewing neuronal populations and projections in the intact mammalian
brain are needed, but light scattering prevents imaging deep into brain structures. We …

Many thousands of cortical neurons are activated by any single sensory stimulus, but the
organization of these populations is poorly understood. For example, are neurons in mouse …

The brain is a highly adaptable organ that is capable of converting sensory information into
changes in neuronal function. This plasticity allows behavior to be accommodated to the …

Abstract miR-132 is a CREB-induced microRNA that is involved in dendritic spine plasticity.
We found that visual experience regulated histone post-translational modifications at a CRE …

Modifications of neuronal circuits allow the brain to adapt and change with experience. This
plasticity manifests during development and throughout life, and can be remarkably long …

Induction of the activity-regulated cytoskeleton-associated protein gene (Arc), one of the
immediate early genes, in the brain correlates with various sensory processes, natural …

Acquiring the behavioral significance of sound has repeatedly been shown to correlate with
long term changes in response properties of neurons in the adult primary auditory cortex …

Neural activity during vertebrate development has been unambiguously shown to play a
critical role in sculpting circuit formation and function. Patterned neural activity in various …