The global popularity of herbal supplements and the promise they hold in treating various
disease states has caused an unprecedented interest in understanding the molecular basis …

Understanding mechanisms of aging and determinants of life span will help to reduce age-
related morbidity and facilitate healthy aging. Average lifespan has increased over the last …

Heme oxygenases (HOs) are the rate-limiting enzymes in the catabolism of heme into
biliverdin, free iron, and carbon monoxide. Two genetically distinct isoforms of HO have …

Oxidative stress is a major component of harmful cascades activated in neurodegenerative
disorders. We sought to elucidate possible effects of alginate oligosaccharide (AOS) on H 2 …

Oxidative stress is a common etiological feature of neurological disorders, although the
pathways that govern defence against reactive oxygen species (ROS) in neurodegeneration …

Alzheimer's disease (AD) brain is characterized by amyloid β-peptide (Aβ) deposits,
neurofibrillary tangles, synapse loss, and extensive oxidative stress. Aβ-induced oxidative …

Carnosine (β-alanyl-l-histidine) is a natural dipeptide widely and abundantly distributed in
excitable tissues of several animal tissues. Although its physiological role has not been …

Molecular chaperones are central to cellular protein homeostasis. In mammals, protein
misfolding diseases and aging cause inflammation and progressive tissue loss, in …

The NF-E2-related factor 2 (Nrf2) is a key transcriptional regulator of antioxidant defense
and detoxification. To directly monitor stabilization of Nrf2, we fused its Neh2 domain …

Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in children and is
characterized by reduced aerobic cerebral energy metabolism early after injury, possibly …