Asthma affects nearly 300 million people worldwide. The majority respond to inhaled
corticosteroid treatment with or without beta-adrenergic agonists. However, a subset of 5 to …

Systemic sclerosis (SSc) has the highest fatality rate among connective tissue diseases and
is characterized by vascular damage, inflammation and fibrosis. Currently, no therapy has …

Th2‐dominated immune responses are believed to contribute to the pathogenesis of atopic
dermatitis (AD). IL‐4 and IL‐13 are typical pleiotropic Th2 cytokines that play a central role in …

Background: Asthma is a common respiratory disease caused by genetic and environmental
factors. It has been suggested that TGF-β1, IL-4 and IL-13 play important roles in asthma …

Asthma is a heterogeneous disease for which a strong genetic basis is firmly established.
Although the generally accepted definition includes three domains of symptoms (variable …

Background The IL4, IL13, and IL4 receptor α chain (IL4RA) genes are candidate genes for
atopic diseases. We hypothesized that the polymorphisms in these genes are associated …

Abstract Interleukin (IL)-10 is a regulatory cytokine of the helper T cell type 2 (TH2) pathway,
which underlies both the host defense to helminthic infection and atopic diseases, including …

BACKGROUND: The role of interleukin (IL) 13 and IL-17A in aspirin-exacerbated respiratory
disease (AERD) remains unknown. OBJECTIVE: To analyze the IL-13 and IL-17A gene …

Specific binding members, in particular human anti-IL-13 antibody molecules and especially
those which neutralize IL-13 activity. Methods for using anti-IL-13 antibody mol ecules in …

Background and objective: Polymorphisms in the IL13 gene have been reported to be
associated with susceptibility to asthma. However, a number of studies have shown …