Heterogeneity in multiple sclerosis: scratching the surface of a complex disease

G Disanto, AJ Berlanga, AE Handel… - Autoimmune …, 2011 - Wiley Online Library
Multiple Sclerosis (MS) is the most common demyelinating disease of the central nervous
system. Although the etiology and the pathogenesis of MS has been extensively …

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Nature, 2011 - nature.com
Multiple sclerosis is a common disease of the central nervous system in which the interplay
between inflammatory and neurodegenerative processes typically results in intermittent …

Relationship between HLA-DRB1 polymorphism and susceptibility or resistance to multiple sclerosis in Caucasians: a meta-analysis of non-family-based studies

Q Zhang, CY Lin, Q Dong, J Wang, W Wang - Autoimmunity reviews, 2011 - Elsevier
Objective To identify the contribution of HLA-DRB1 alleles to susceptibility or resistance to
multiple sclerosis (MS) in Caucasians through a meta-analysis of non-family-based studies …

HLA-DPB1* 0501 is associated with susceptibility to anti-aquaporin-4 antibodies positive neuromyelitis optica in Southern Han Chinese

H Wang, Y Dai, W Qiu, X Zhong, A Wu, Y Wang… - Journal of …, 2011 - Elsevier
OBJECTIVES: To analyze the role of HLA-DRB1 and-DPB1 alleles in the pathogenesis of
neuromyelitis optica (NMO) and multiple sclerosis in Southern Han Chinese. METHODS …

Polymorphisms in the Receptor Tyrosine Kinase MERTK Gene Are Associated with Multiple Sclerosis Susceptibility

GZM Ma, J Stankovich… - PLoS one, 2011 - journals.plos.org
Multiple sclerosis (MS) is a debilitating, chronic demyelinating disease of the central nervous
system affecting over 2 million people worldwide. The TAM family of receptor tyrosine …

Role of HLA class II genes in susceptibility and resistance to multiple sclerosis: studies using HLA transgenic mice

D Luckey, D Bastakoty, AK Mangalam - Journal of autoimmunity, 2011 - Elsevier
Multiple sclerosis (MS), an inflammatory and demyelinating autoimmune disease of CNS
has both, a genetic and an environmental predisposition. Among all the genetic factors …

Natural history of multiple sclerosis: long-term prognostic factors

C Renoux - Neurologic clinics, 2011 - neurologic.theclinics.com
Multiple sclerosis (MS) is a chronic neurologic disease with onset occurring predominantly
in young adults. As such, the disease evolves throughout several decades and the affected …

Heterogeneity at the HLA-DRB1 allelic variation locus does not influence multiple sclerosis disease severity, brain atrophy or cognition

A Van der Walt, J Stankovich, M Bahlo… - Multiple Sclerosis …, 2011 - journals.sagepub.com
Background: HLA-DRB1* 1501 (DR15) and other HLA class II alleles increase the risk of
developing multiple sclerosis (MS). However, the contribution of genetic heterogeneity to the …

HLA-DR allele polymorphism and multiple sclerosis in Chinese populations: a meta-analysis

W Qiu, I James, WM Carroll… - Multiple Sclerosis …, 2011 - journals.sagepub.com
Background: The association of human leukocyte antigen (HLA) genes and multiple
sclerosis (MS) has been extensively investigated in Caucasians, but less so in Oriental …

HLA‐DRB1: genetic susceptibility and disability progression in a Spanish multiple sclerosis population

L Romero‐Pinel, JM Pujal… - European Journal of …, 2011 - Wiley Online Library
Background and objective: The association of HLA‐DRB1* 15 with susceptibility to multiple
sclerosis (MS) has been consistently reported although its effect on the clinical phenotype is …