Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease characterised by alveolar
accumulation of surfactant. It may result from mutations in surfactant proteins or granulocyte …

Pulmonary alveolar proteinosis is a rare but potentially treatable disease, characterized by
impaired surfactant metabolism that leads to accumulation in the alveoli of proteinaceous …

Since the identification of surfactant deficiency as the putative cause of the infant respiratory
distress syndrome (RDS) by Avery and Mead in 1959, our understanding of the role of …

This book encapsulates over three decades of the author's work on comparative functional
respiratory morphology. It provides insights into the mechanism (s) by which respiratory …

Opinion statement Lung transplantation in children is an effective treatment for end-stage
pulmonary disease after all medical therapy has failed. It requires a huge investment in …

Pulmonary alveolar proteinosis (PAP) is a rare condition in which pulmonary macrophages
fail to clear surfactant, resulting in the alveolar accumulation of lipoproteinaceous debris …

Reconstruction of the changes that have occurred during the evolution of the gas
exchangers is riddled with pitfalls. This is mainly because of the almost complete lack of …

The development of an embryo is instructed by the vast information encoded in the genome.
Transactions of information contained in the DNA direct the system-wide spatial and …