Improving the stability of aptamers by chemical modification

RE Wang, H Wu, Y Niu, J Cai - Current medicinal chemistry, 2011 - ingentaconnect.com
Ever since the invention of SELEX (systematic evolution of ligands by exponential
enrichment), there has been rapid development for aptamers over the last two decades …

Nucleic acid aptamers targeting cell-surface proteins

P Dua, S Kim, D Lee - Methods, 2011 - Elsevier
Aptamers are chemical antibodies that bind to their targets with high affinity and specificity.
These short stretches of nucleic acids are identified using a repetitive in vitro selection and …

[HTML][HTML] Inhibition of cell proliferation by an anti-EGFR aptamer

N Li, HH Nguyen, M Byrom, AD Ellington - PloS one, 2011 - journals.plos.org
Aptamers continue to receive interest as potential therapeutic agents for the treatment of
diseases, including cancer. In order to determine whether aptamers might eventually prove …

Reversible targeting and controlled release delivery of daunorubicin to cancer cells by aptamer-wrapped carbon nanotubes

SM Taghdisi, P Lavaee, M Ramezani… - European journal of …, 2011 - Elsevier
AIM: Single-walled carbon nanotubes (SWNTs) have been already used as drug carriers. In
this study, we introduced sgc8c aptamer (this aptamer targets leukemia biomarker protein …

Cell‐specific aptamers as emerging therapeutics

C Meyer, U Hahn, A Rentmeister - Journal of nucleic acids, 2011 - Wiley Online Library
Aptamers are short nucleic acids that bind to defined targets with high affinity and specificity.
The first aptamers have been selected about two decades ago by an in vitro process named …

[HTML][HTML] Methods to identify aptamers against cell surface biomarkers

A Cibiel, DM Dupont, F Ducongé - Pharmaceuticals, 2011 - mdpi.com
Aptamers are nucleic acid-based ligands identified through a process of molecular evolution
named SELEX (Systematic Evolution of Ligands by Exponential enrichment). During the last …

Recent developments in protein and cell-targeted aptamer selection and applications

J Liu, M You, Y Pu, H Liu, M Ye… - Current medicinal …, 2011 - ingentaconnect.com
Because of their easily modified chemical structures and wide range of targets, aptamers are
ideal candidates for various applications, such as biomarker discovery, target diagnosis …

ssDNA aptamer-based column for simultaneous removal of nanogram per liter level of illicit and analgesic pharmaceuticals in drinking water

X Hu, L Mu, Q Zhou, J Wen… - Environmental science & …, 2011 - ACS Publications
Aptamers are a new class of single-stranded DNA/RNA molecules selected from synthetic
nucleic acid libraries for molecular recognition. Our group reports a novel aptamer column …

[PDF][PDF] Current concepts and new developments for autologous in vivo endothelialisation of biomaterials for intravascular applications

M Avci-Adali, N Perle, G Ziemer, HP Wendel - Eur Cell Mater, 2011 - researchgate.net
Circulating endothelial progenitor cells (EPCs) in the peripheral blood of adults represent an
auspicious cell source for tissue engineering of an autologous endothelium on blood …

The selection of aptamers specific for membrane molecular targets

T Janas, T Janas - Cellular & molecular biology letters, 2011 - Springer
A growing number of RNA aptamers have been selected experimentally using the SELEX
combinatorial approach, and these aptamers have several advantages over monoclonal …