The phenomenon of treatment-resistant depression (TRD), described as the occurrence of
an inadequate response after an adequate treatment with antidepressant agents (in terms of …

Context Cognitive impairment in late-life depression is a core feature of the illness. Objective
To test whether donepezil hydrochloride and antidepressant therapy is superior to placebo …

Switching Antidepressant Class Does Not Improve Response or... : Journal of Clinical
Psychopharmacology Switching Antidepressant Class Does Not Improve Response or …

BackgroundAlthough many studies suggest that, on average, depression-specific
psychotherapy and antidepressant pharmacotherapy are efficacious, we know relatively little …

Major depressive disorder (MDD) is currently ranked the third leading cause of disability in
the world. Treatment-resistant depression (TRD) causes the majority of MDD disability …

Background: Many patients with major depressive disorder (MDD) who achieve full
remission after antidepressant treatment still have residual depressive symptoms. In this …

Considerable evidence from various studies suggests a preeminent role for early adverse
experiences in the development of psychopathology, especially depression. The most …

Brain-derived neurotrophic factor (BDNF), a member of the nerve growth factor family of
neurotrophins, has pivotal roles in neuronal survival, proliferation, and synaptic plasticity in …

Only 50% of depressed patients achieve remission of symptoms after 2 trials of
antidepressants. Therefore one half of patients are considered treatment resistant. Studies …

Aims: Selective serotonin reuptake inhibitors (SSRIs) are the most commonly used class of
antidepressants for treating major depression. However, approximately 30% of patients do …