Gammaherpesviruses are lymphotropic viruses that are associated with the development of
lymphoproliferative diseases, lymphomas, as well as other nonlymphoid cancers. Most …

Abstract According to World Health Organization estimates, infectious organisms are
responsible for approximately one in four deaths worldwide. Animal models play an …

Phosphorylation represents one the most abundant and important posttranslational
modifications of proteins, including viral proteins. Virus-encoded serine/threonine protein …

Human respiratory syncytial virus (RSV), a leading cause of respiratory tract infections in
infants, inhibits type I interferon (IFN)-dependent signalling, as well as IFN synthesis. RSV …

Innate cellular immunity is the immediate host response against pathogens, and activation of
innate immunity also modulates the induction of adaptive immunity. The nucleotide-binding …

During a lytic gammaherpesvirus infection, host gene expression is severely restricted by
the global degradation and altered 3′ end processing of mRNA. This host shutoff …

Gammaherpesviruses such as KSHV and EBV establish lifelong persistent infections
through latency in lymphocytes. These viruses have evolved several strategies to counteract …

The innate immune response constitutes the first line of host defence that limits viral spread
and plays an important role in the activation of adaptive immune response. Viral …

Upon viral infection, m itochondrial a nti v iral s ignaling (MAVS) protein serves as a key
adaptor to promote cytokine production. We report here that murine gamma herpesvirus 68 …

Viral invasion of a host cell triggers immune responses with both innate and adaptive
components. The innate immune response involving the induction of type I interferons …