Epidemiology and etiology of Parkinson's disease: a review of the evidence

K Wirdefeldt, HO Adami, P Cole, D Trichopoulos… - European journal of …, 2011 - Springer
The etiology of Parkinson's disease (PD) is not well understood but likely to involve both
genetic and environmental factors. Incidence and prevalence estimates vary to a large …

Potential mechanisms underlying anxiety and depression in Parkinson's disease: consequences of l-DOPA treatment

KLE Jaunarajs, M Angoa-Perez, DM Kuhn… - … & Biobehavioral Reviews, 2011 - Elsevier
Though the most recognizable symptoms of Parkinson's disease (PD) are motor-related,
many patients also suffer from debilitating affective symptoms that deleteriously influence …

Factors associated with depression in Parkinson's disease

NNW Dissanayaka, A Sellbach, PA Silburn… - Journal of affective …, 2011 - Elsevier
BACKGROUND: Depression is common in Parkinson's disease (PD) and contributes
significantly to a reduced quality of life in PD patients. The determinants of depression in PD …

Neurobiology of Depression and Anxiety in Parkinson′ s Disease

O Kano, K Ikeda, D Cridebring, T Takazawa… - Parkinson's …, 2011 - Wiley Online Library
Depression and anxiety are common in Parkinson′ s disease (PD) and have important
consequences on quality of life. These have long been recognized as frequent …

[PDF][PDF] Emotional dysfunction in Parkinson's disease

LX Blonder, JT Slevin - Behavioural neurology, 2011 - Wiley Online Library
In addition to motor symptomatology, idiopathic Parkinson's disease is characterized by
emotional dysfunction. Depression affects some 30 to 40 percent of Parkinson patients and …

Prevalence of depression in Parkinson's disease: effects of disease stage, motor subtype and gender

TC van der Hoek, BAA Bus, P Matui… - Journal of the …, 2011 - Elsevier
Depression is one of the most common non-motor symptoms of Parkinson's disease (PD)
with a large negative impact on the quality of life. Factors such as disease stage, subtype of …

Serotonin-dependent depression in Parkinson's disease: A role for the subthalamic nucleus?

SKH Tan, H Hartung, T Sharp, Y Temel - Neuropharmacology, 2011 - Elsevier
Depression is the most common neuropsychiatric co-morbidity in Parkinson's disease (PD).
The underlying mechanism of depression in PD is complex and likely involves biological …

[HTML][HTML] Neuroimaging in Parkinson's disease

AJ Stoessl - Neurotherapeutics, 2011 - Elsevier
Parkinson's disease (PD) is a common disorder in which the primary features can be related
to dopamine deficiency. Changes on structural imaging are limited, but a wealth of …

Progress in defining the premotor phase of Parkinson's disease

E Tolosa, C Pont-Sunyer - Journal of the neurological sciences, 2011 - Elsevier
Several studies have suggested that a variety of non-motor symptoms (NMS) frequently
antedate the development of the classical motor symptoms in Parkinson's disease (PD) …

Mood and cognition in leucine‐rich repeat kinase 2 G2019S Parkinson's disease

V Shanker, M Groves, G Heiman… - Movement …, 2011 - Wiley Online Library
The behavioral and cognitive features of the leucine‐rich repeat kinase G2019S mutation in
Parkinson's disease in the Ashkenazi Jewish population are not well described; therefore …