Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box

JW Kronstad, R Attarian, B Cadieux, J Choi… - Nature reviews …, 2011 - nature.com
Cryptococcus neoformans is generally considered to be an opportunistic fungal pathogen
because of its tendency to infect immunocompromised individuals, particularly those …

The TB Structural Genomics Consortium: a decade of progress

N Chim, JE Habel, JM Johnston, I Krieger, L Miallau… - Tuberculosis, 2011 - Elsevier
The TB Structural Genomics Consortium is a worldwide organization of collaborators whose
mission is the comprehensive structural determination and analyses of Mycobacterium …

Cell wall chitosan is necessary for virulence in the opportunistic pathogen Cryptococcus neoformans

LG Baker, CA Specht, JK Lodge - Eukaryotic cell, 2011 - Am Soc Microbiol
Cryptococcus neoformans is an opportunistic fungal pathogen that causes
meningoencephalitis. Its cell wall is composed of glucans, proteins, chitin, and chitosan …

Dynamics of Cryptococcus neoformans-macrophage interactions reveal that fungal background influences outcome during cryptococcal meningoencephalitis in …

A Alanio, M Desnos-Ollivier, F Dromer - MBio, 2011 - Am Soc Microbiol
Cryptococcosis is a multifaceted fungal infection with variable clinical presentation and
outcome. As in many infectious diseases, this variability is commonly assigned to host …

Toward an Integrated Model of Capsule Regulation in Cryptococcus neoformans

BC Haynes, ML Skowyra, SJ Spencer, SR Gish… - PLoS …, 2011 - journals.plos.org
Cryptococcus neoformans is an opportunistic fungal pathogen that causes serious human
disease in immunocompromised populations. Its polysaccharide capsule is a key virulence …

Role of IL-17A on Resolution of Pulmonary C. neoformans Infection

KL Wozniak, SE Hardison, JK Kolls, FL Wormley Jr - PLos one, 2011 - journals.plos.org
The current studies evaluated the role of interleukin (IL)-17A in the induction of protective
immunity against pulmonary cryptococcosis in mice. Protection against pulmonary infection …

Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host

MS Price, M Betancourt-Quiroz, JL Price, DL Toffaletti… - MBio, 2011 - Am Soc Microbiol
Cryptococcus neoformans is an important fungal pathogen of immunocompromised
individuals, with a close relative, Cryptococcus gattii, emerging as a serious threat for the …

Role for Golgi reassembly and stacking protein (GRASP) in polysaccharide secretion and fungal virulence

L Kmetzsch, LS Joffe, CC Staats… - Molecular …, 2011 - Wiley Online Library
Secretion of virulence factors is a critical mechanism for the establishment of cryptococcosis,
a disease caused by the yeast pathogen Cryptococcus neoformans. One key virulence …

Nitrogen Metabolite Repression of Metabolism and Virulence in the Human Fungal Pathogen Cryptococcus neoformans

IR Lee, EWL Chow, CA Morrow, JT Djordjevic… - Genetics, 2011 - academic.oup.com
Proper regulation of metabolism is essential to maximizing fitness of organisms in their
chosen environmental niche. Nitrogen metabolite repression is an example of a regulatory …

Cryptococcus gattii Virulence Composite: Candidate Genes Revealed by Microarray Analysis of High and Less Virulent Vancouver Island Outbreak Strains

P Ngamskulrungroj, J Price, T Sorrell, JR Perfect… - PLoS …, 2011 - journals.plos.org
Human and animal cryptococcosis due to an unusual molecular type of Cryptococcus gattii
(VGII) emerged recently on Vancouver Island, Canada. Unlike C. neoformans, C. gattii …