DNA replicases from a bacterial perspective

CS McHenry - Annual review of biochemistry, 2011 - annualreviews.org
Bacterial replicases are complex, tripartite replicative machines. They contain a polymerase,
polymerase III (Pol III), a β2 processivity factor, and a DnaX complex ATPase that loads β2 …

Bacterial replicases and related polymerases

CS McHenry - Current opinion in chemical biology, 2011 - Elsevier
Bacterial replicases are complex, tripartite replicative machines. They contain a polymerase,
Pol III, a β2 processivity factor and a DnaX complex ATPase that loads β2 onto DNA and …

Evaluation of model quality predictions in CASP9

A Kryshtafovych, K Fidelis… - … : Structure, Function, and …, 2011 - Wiley Online Library
CASP has been assessing the state of the art in the a priori estimation of accuracy of protein
structure prediction since 2006. The inclusion of model quality assessment category in …

Breaking the rules: bacteria that use several DNA polymerase IIIs

CS McHenry - EMBO reports, 2011 - embopress.org
Studies using Escherichia coli DNA polymerase (Pol) III as the prototype for bacterial DNA
replication have suggested that—in contrast to eukaryotes—one replicase performs all of the …

Identification of a chemical that inhibits the mycobacterial UvrABC complex in nucleotide excision repair

N Mazloum, MA Stegman, DL Croteau… - Biochemistry, 2011 - ACS Publications
Bacterial DNA can be damaged by reactive nitrogen and oxygen intermediates (RNI and
ROI) generated by host immunity, as well as by antibiotics that trigger bacterial production of …

[HTML][HTML] The flexibility of UV-inducible mutation in Deinococcus ficus as evidenced by the existence of the imuB–dnaE2 gene cassette and generation of superior …

YH Zeng, FT Shen, CC Tan, CC Huang… - Microbiological research, 2011 - Elsevier
The lexA–imuB–dnaE2 gene cassette contributing to the TLS (translesion synthesis)
polymerase activity and can easily cause mutation after DNA damage in many bacteria. But …

Making ends meet in mycobacteria

DF Warner, V Mizrahi - Molecular microbiology, 2011 - Wiley Online Library
Genotoxic agents from endogenous and exogenous sources cause double‐strand breaks
(DSBs) in chromosomal DNA. Given the threat these lesions pose to viability, it is not …

[PDF][PDF] The fitness costs of drug resistance mutations in Mycobacteria

AS Koch - 2011 - wiredspace.wits.ac.za
The increasing emergence of drug-resistant pathogens poses a major threat to public
health. Although influenced by multiple factors, resistance is often associated with mutations …