The process of post-lactational regression, or involution, of the mammary gland is a complex
event characterised by extensive death of the secretory epithelium coupled with remodelling …

STAT5 consists of two proteins, STAT5A/B, that impact mammary cell differentiation,
proliferation, and survival. In normal development, STAT5 expression and activity are …

A potential role for epigenetic mechanisms in the regulation of mammary function in the
dairy cow is emerging. Epigenetics is the study of heritable changes in genome function that …

The role of Stat5 in maintaining adequate lactation was studied in Stat5a−/− mice
expressing a conditionally suppressed transgenic STAT5 in their mammary glands. This …

Abstract Introduction Protein tyrosine kinases (PTKs) are frequently overexpressed and/or
activated in human malignancies, and regulate cancer cell proliferation, cellular survival …

Post-lactational involution of the mammary gland is initiated within days of weaning.
Clearing of cells occurs by apoptosis of the milk-secreting luminal cells in the alveoli and …

Genetically engineered mice along with allograft and xenograft models can be used to
effectively model triple negative breast cancer both for studies of pathophysiology as well as …

Breast cancer is a heterogeneous disease with distinct subtypes that are predictive of patient
prognosis. Luminal subtype tumors confer the most favorable prognosis due to ERα …

Mouse mammary gland morphogenesis at puberty is a complex developmental process,
regulated by systemic hormones, local growth factors and dependent on the …

The ability of exogenous growth hormone (GH) to increase milk yield through insulin-like
growth factor-1 (IGF-I) in dairy cows is well characterized. However, recent studies utilizing …