A decade has elapsed since the concept of oncogene addiction was first proposed. It
postulates that–despite the diverse array of genetic lesions typical of cancer–some tumours …

Epithelial-mesenchymal transition (EMT) is a tightly regulated process that is critical for
embryogenesis but is abnormally activated during cancer metastasis and recurrence. Here …

Advanced human thyroid cancers, particularly those that are refractory to treatment with
radioiodine (RAI), have a high prevalence of BRAF (v-raf murine sarcoma viral oncogene …

High-throughput technologies can now identify hundreds of candidate protein biomarkers for
any disease with relative ease. However, because there are no assays for the majority of …

PIK3CA gain-of-function mutations are a common oncogenic event in human malignancy,,,,
making phosphatidylinositol 3-kinase (PI3K) a target for cancer therapy. Despite the promise …

Genetically engineered mice are critical experimental models for the study of breast cancer
biology. Transgenic mice, employing strong mammary epithelial promoters to drive …

We investigated the potential of in-depth quantitative proteomics to reveal plasma protein
signatures that reflect lung tumor biology. We compared plasma protein profiles of four …

Tumor development relies upon essential contributions from the tumor microenvironment
and host immune alterations. These contributions may inform the plasma proteome in a …

The microenvironment of the mammary gland has been shown to exert a deterministic
control over cells from different normal organs during murine mammary gland regeneration …

KRAS is a potent oncogene and is mutated in about 30% of all human cancers. However,
the biological context of KRAS-dependent oncogenesis is poorly understood. Genetically …