Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question
Nonsense-mediated mRNA decay (NMD) is a well-studied cellular quality-control pathway. It
decreases the half-lives of eukaryotic mRNAs that aberrantly contain premature termination …
decreases the half-lives of eukaryotic mRNAs that aberrantly contain premature termination …
Autoregulation of the nonsense-mediated mRNA decay pathway in human cells
H Yepiskoposyan, F Aeschimann, D Nilsson… - Rna, 2011 - rnajournal.cshlp.org
Nonsense-mediated mRNA decay (NMD) is traditionally portrayed as a quality-control
mechanism that degrades mRNAs with truncated open reading frames (ORFs). However, it …
mechanism that degrades mRNAs with truncated open reading frames (ORFs). However, it …
RNA homeostasis governed by cell type-specific and branched feedback loops acting on NMD
Nonsense-mediated mRNA decay (NMD) is a conserved RNA decay pathway that degrades
aberrant mRNAs and directly regulates many normal mRNAs. This dual role for NMD raises …
aberrant mRNAs and directly regulates many normal mRNAs. This dual role for NMD raises …
Pleiotropic functions of EAPII/TTRAP/TDP2: cancer development, chemoresistance and beyond
EAPII (also called TTRAP, TDP2), a protein identified a decade ago, has recently been
shown to function as an oncogenic factor. This protein was also proven to be the first 5' …
shown to function as an oncogenic factor. This protein was also proven to be the first 5' …
Pyrimidine pool imbalance induced by BLM helicase deficiency contributes to genetic instability in Bloom syndrome
P Chabosseau, G Buhagiar-Labarchède… - Nature …, 2011 - nature.com
Defects in DNA replication are associated with genetic instability and cancer development,
as illustrated in Bloom syndrome. Features of this syndrome include a slowdown in …
as illustrated in Bloom syndrome. Features of this syndrome include a slowdown in …
The classification of mRNA expression levels by the phosphorylation state of RNAPII CTD based on a combined genome-wide approach
Background Cellular function is regulated by the balance of stringently regulated amounts of
mRNA. Previous reports revealed that RNA polymerase II (RNAPII), which transcribes …
mRNA. Previous reports revealed that RNA polymerase II (RNAPII), which transcribes …
Identification d'inhibiteurs du nonsense-mediated mRNA decay (NMD) et utilisation comme approche thérapeutique dans certaines maladies génétiques
SS Gonzalez-Hilarion - 2011 - theses.hal.science
Le NMD (nonsense-mediated mRNA decay) est un mécanisme qui reconnaît et dégrade les
ARNm portant un codon stop prématuré afin d'empêcher la synthèse de protéines tronquées …
ARNm portant un codon stop prématuré afin d'empêcher la synthèse de protéines tronquées …
[PDF][PDF] 2. Le mécanisme du NMD
UPF hUPF, SMG hSMG, SMG hSMG… - … d'inhibiteurs du …, 2011 - Citeseer
One third of genetic inherited diseases involve a premature termination codon (PTC)[1]. In
most cases, the primary mechanism whereby a nonsense mutation has an effect is through …
most cases, the primary mechanism whereby a nonsense mutation has an effect is through …
Regulation of Core Splicing Factors by Alternative Splicing and Nonsense-mediated mRNA Decay
A Saltzman - 2011 - library-archives.canada.ca
Abstract<? Pub Inc> The majority of human genes are transcribed into a precursor
messenger RNA (pre-mRNA) that is processed to produce multiple mRNA variants through …
messenger RNA (pre-mRNA) that is processed to produce multiple mRNA variants through …