RAS proteins are essential components of signalling pathways that emanate from cell
surface receptors. Oncogenic activation of these proteins owing to missense mutations is …

Considered during the past decades as cell dust, microparticles are now deemed true
biomarkers and vectors of biological information between cells. Depending on their origin …

The ability of cancer cells to break out of tissue compartments and invade locally gives solid
tumours a defining deadly characteristic. One of the first steps of invasion is the remodelling …

The timing of decidualisation and vascular processes during the implantation period is of
paramount importance for the development of a receptive endometrium suitable for …

Gliomas are highly invasive, lethal brain tumors. Tumor-associated proteases play an
important role in glioma progression. Annexin A2 is overexpressed in many cancers and …

Enzyme-responsive protein nanocapsules are synthesized to release their protein cargoes
in response to specific enzymes secreted in certain cellular events not only with specificity …

Endothelial cells form the inner lining of vascular networks and maintain blood fluidity by
inhibiting blood coagulation and promoting blood clot dissolution (fibrinolysis). Plasmin, the …

Abstract Background In the vasculature, Notch signaling functions as a downstream effecter
of Vascular Endothelial Growth Factor (VEGF) signaling. VEGF regulates sprouting …

The success of cancer therapy can be difficult to predict, as its efficacy is often predicated
upon characteristics of the cancer, treatment, and individual that are not fully understood or …

Angiogenesis is very important for vascularized tissue engineering. In this study, we found
that a two-dimensional co-culture of human bone marrow stromal cell (HBMSC) and human …