Retinoids are ubiquitous signaling molecules that influence nearly every cell type, exert
profound effects on development, and complement cancer chemotherapeutic regimens. All …

Oral isotretinoin (13-cis retinoic acid) is the most effective drug in the treatment of acne and
restores all major pathogenetic factors of acne vulgaris. Isotretinoin is regarded as a prodrug …

Background It has been documented all-trans retinoic acid (atRA) promotes the
development of TGF-β-induced CD4+ Foxp3+ regulatory T cells (iTreg) that play a vital role …

Loss of memory B cells occurs from the onset of HIV-1 infection and persists into the chronic
stages of infection. Lack of survival of these cells, even in subjects being treated, could …

For a long time, it was commonly believed that efficient anticancer regimens would either
trigger the apoptotic demise of tumor cells or induce a permanent arrest in the G1 phase of …

Pigment epithelium-derived factor (PEDF) is an intrinsic anti-angiogenic factor and a
potential anti-tumor agent. The tumoricidal mechanism of PEDF, however, has not been fully …

Forkhead FoxO transcription factors exert critical biological functions in response to
genotoxic stress. In mammals four FoxOs proteins are known. FoxOs induce cell cycle arrest …

Apolipoprotein E (apoE) is an important plasma protein in cholesterol homeostasis and
plays a key role in the progression of glomerulosclerosis (GS). We conducted this …

Introduction: TNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family
of cytokines, and shows promising therapeutic activity against solid tumors and lymphomas …

Síndromes Mielodisplásicas (SMD) compreendem um conjunto heterogêneo de doenças
hematopoéticas caracterizadas por hematopoese ineficaz, que geralmente apresentam …