Chronic antigenic stimulation leads to gradual accumulation of late‐differentiated, antigen‐
specific, oligoclonal T cells, particularly within the CD8+ T‐cell compartment. They are …

The immune system of an organism is an essential component of the defense mechanism
aimed at combating pathogenic stress. Age-associated immune dysfunction, also dubbed …

Senescent T-cells accumulate with age, lowering the naïve T-cell repertoire and increasing
host infection risk. As this response is likely to be influenced by certain lifestyle factors, we …

Both humoral and cellular immune responses are impaired in aged individuals, leading to
decreased vaccine responses. Although T cell defects occur, defects in B cells play a …

“Immune senescence” is a descriptive term for the deleterious age-associated changes to
immunity observed in all mammals studied so far. While all components of innate and …

As humans age, their immune systems undergo a process known as immunosenescence.
This global aging of the immune system is associated with increased susceptibility to …

The immune system is affected by the aging process and undergoes significant age-related
changes, termed immunosenescence. Different T cell subsets are affected by this process …

The most profound consequences of immune senescence with respect to public health are
the increased susceptibility to influenza and loss of efficacy of the current split-virus …

Aging represents a complex remodeling in which both innate and adaptive immunities
deteriorate. Age-related changes in humoral immunity are responsible for the reduced …

Aging of the immune system is a major factor responsible for the increased severity of
infections, reduced responses to vaccines, and higher cancer incidence in the elderly. A …