Pathophysiological mechanisms of atrial fibrillation: a translational appraisal
U Schotten, S Verheule, P Kirchhof… - Physiological …, 2011 - journals.physiology.org
Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different
pathophysiological processes in the atria. Some aspects of the morphological and …
pathophysiological processes in the atria. Some aspects of the morphological and …
Recent advances in the molecular pathophysiology of atrial fibrillation
Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes
substantial morbidity and contributes to mortality. The mechanisms underlying AF are …
substantial morbidity and contributes to mortality. The mechanisms underlying AF are …
The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with
substantial morbidity and mortality. It causes profound changes in sarcoplasmic reticulum …
substantial morbidity and mortality. It causes profound changes in sarcoplasmic reticulum …
Differential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling
Rationale: Atrial fibrillation (AF) causes atrial-tachycardia remodeling (ATR), with enhanced
constitutive acetylcholine-regulated K+ current (IKAChC) contributing to action potential …
constitutive acetylcholine-regulated K+ current (IKAChC) contributing to action potential …
Effects of a Highly Selective Acetylcholine-Activated K+ Channel Blocker on Experimental Atrial Fibrillation
T Machida, N Hashimoto, I Kuwahara… - Circulation …, 2011 - Am Heart Assoc
Background—The acetylcholine-activated K+ current (IK, ACh) is a novel candidate for atrial-
specific antiarrhythmic therapy. The present study investigates the involvement of IK, ACh in …
specific antiarrhythmic therapy. The present study investigates the involvement of IK, ACh in …
Discovery, characterization, and structure–activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2. 3, Kir3. x, and Kir7. 1
R Raphemot, DF Lonergan, TT Nguyen… - Frontiers in …, 2011 - frontiersin.org
The inward rectifier family of potassium (Kir) channels is comprised of at least 16 family
members exhibiting broad and often overlapping cellular, tissue, or organ distributions. The …
members exhibiting broad and often overlapping cellular, tissue, or organ distributions. The …
Novel pharmacological targets for the rhythm control management of atrial fibrillation
A Burashnikov, C Antzelevitch - Pharmacology & therapeutics, 2011 - Elsevier
Atrial fibrillation (AF) is a growing clinical problem associated with increased morbidity and
mortality. Development of safe and effective pharmacological treatments for AF is one of the …
mortality. Development of safe and effective pharmacological treatments for AF is one of the …
Atrial remodeling in atrial fibrillation and some related microRNAs
D Sharma, G Li, G Xu, Y Liu, Y Xu - Cardiology, 2011 - karger.com
Atrial fibrillation is the most common sustained arrhythmia associated with substantial
cardiovascular morbidity and mortality, with stroke being the most critical complication. The …
cardiovascular morbidity and mortality, with stroke being the most critical complication. The …
Atrial remodeling and novel pharmacological strategies for antiarrhythmic therapy in atrial fibrillation
N Jost, Z Kohajda, AA Kristof… - Current medicinal …, 2011 - ingentaconnect.com
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. It can occur at any
age, however, it becomes extremely common in the elderly, with a prevalence approaching …
age, however, it becomes extremely common in the elderly, with a prevalence approaching …
[PDF][PDF] Ion channel remodelling in atrial fibrillation
Atrial fibrillation (AF) is the most common arrhythmia and is associated with substantial
cardiovascular morbidity and mortality, with stroke being the most critical complication …
cardiovascular morbidity and mortality, with stroke being the most critical complication …