MicroRNAs in development and disease
D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …
introduced an additional level of intricacy to our understanding of gene regulation. There are …
miRNAs in human cancer
TA Farazi, JI Spitzer, P Morozov… - The Journal of …, 2011 - Wiley Online Library
Mature microRNAs (miRNAs) are single‐stranded RNA molecules of 20–23 nucleotide (nt)
length that control gene expression in many cellular processes. These molecules typically …
length that control gene expression in many cellular processes. These molecules typically …
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
C Liu, K Kelnar, B Liu, X Chen, T Calhoun-Davis, H Li… - Nature medicine, 2011 - nature.com
Cancer stem cells (CSCs), or tumor-initiating cells, are involved in tumor progression and
metastasis. MicroRNAs (miRNAs) regulate both normal stem cells and CSCs,,,, and …
metastasis. MicroRNAs (miRNAs) regulate both normal stem cells and CSCs,,,, and …
miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
H Siemens, R Jackstadt, S Hünten, M Kaller… - Cell cycle, 2011 - Taylor & Francis
Recently, the inhibition of epithelial-mesenchymal-transition (EMT) by p53 has been
described as a new mode of tumor suppression which presumably prevents metastasis …
described as a new mode of tumor suppression which presumably prevents metastasis …
Biological functions of microRNAs: a review
Y Huang, XJ Shen, Q Zou, SP Wang, SM Tang… - Journal of physiology …, 2011 - Springer
MicroRNAs (miRNAs) are a recently discovered family of endogenous, noncoding RNA
molecules approximately 22 nt in length. miRNAs modulate gene expression post …
molecules approximately 22 nt in length. miRNAs modulate gene expression post …
Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice
P Trang, JF Wiggins, CL Daige, C Cho, M Omotola… - Molecular Therapy, 2011 - cell.com
MicroRNAs (miRNAs) are emerging as potential cancer therapeutics, but effective delivery
mechanisms to tumor sites are a roadblock to utility. Here we show that systemically …
mechanisms to tumor sites are a roadblock to utility. Here we show that systemically …
MicroRNAs and epigenetics
F Sato, S Tsuchiya, SJ Meltzer, K Shimizu - The FEBS journal, 2011 - Wiley Online Library
MicroRNAs (miRNAs) comprise species of short noncoding RNA that regulate gene
expression post‐transcriptionally. Recent studies have demonstrated that epigenetic …
expression post‐transcriptionally. Recent studies have demonstrated that epigenetic …
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition
Snail1 is a zinc finger transcriptional repressor whose pathological expression has been
linked to cancer cell epithelial–mesenchymal transition (EMT) programs and the induction of …
linked to cancer cell epithelial–mesenchymal transition (EMT) programs and the induction of …
[HTML][HTML] MicroRNAs and the cell cycle
MJ Bueno, M Malumbres - Biochimica et Biophysica Acta (BBA)-Molecular …, 2011 - Elsevier
The control of cell proliferation by microRNAs (miRNAs) is well established and the
alteration of these small, non-coding RNAs may contribute to tumor development by …
alteration of these small, non-coding RNAs may contribute to tumor development by …
p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
p53 suppresses tumor progression and metastasis. Epithelial–mesenchymal transition
(EMT) is a key process in tumor progression and metastasis. The transcription factors ZEB1 …
(EMT) is a key process in tumor progression and metastasis. The transcription factors ZEB1 …