The cell imposes multiple barriers to virus entry. However, viruses exploit fundamental
cellular processes to gain entry to cells and deliver their genetic cargo. Virus entry pathways …

Since the isolation of HIV, multiple transmissions are thought to have occurred between man
and other old-world primates. Assessment of samples from apes and human beings with …

The structure of VRC01 in complex with the HIV-1 gp120 core reveals that this broadly
neutralizing CD4 binding site (CD4bs) antibody partially mimics the interaction of the …

Human immunodeficiency virus (HIV) entry is a complex and intricate process that facilitates
delivery of the viral genome to the host cell. The only viral surface protein, Envelope (Env), is …

Human immunodeficiency virus (HIV) infection is principally a mucosal disease and the
gastrointestinal (GI) tract is the major site of HIV replication. Loss of CD4+ T cells and …

Extracellular adenosine triphosphate (ATP) can activate purinergic receptors of the plasma
membrane and modulate multiple cellular functions. We report that ATP is released from HIV …

Virus entry into cells is typically initiated by binding of virally encoded envelope proteins to
specific cell surface receptors. Studying infectivity of lentivirus pseudotypes lacking …

In 1989, a new type of antibody was identified, first in the sera of dromedaries and later also
in all other species of the Camelidae family. These antibodies do not contain a light chain …

It is well established that HIV-1 infection typically involves an interaction between the viral
envelope protein gp120/41 and the CD4 molecule followed by a second interaction with a …

Sexual transmission of human immunodeficiency virus type 1 (HIV-1) across mucosal
barriers is responsible for the vast majority of new infections. This relatively inefficient …