Temperature perception is vital for cellular and metabolic homeostasis, avoidance, and
survival. In the primary afferent nerve terminal, select members of the transient receptor …

Mustard oil (MO) is a plant-derived irritant that has been extensively used in experimental
models to induce pain and inflammation [1, 2]. The noxious effects of MO are currently …

Transient receptor potential channels are important mediators of thermal and mechanical
stimuli and play an important role in neuropathic pain. The contribution of hereditary variants …

Objective To investigate the involvement of transient receptor potential ankyrin 1 (TRPA1) in
inflammatory hyperalgesia mediated by tumor necrosis factor α (TNFα) and joint …

Background Nociceptive sensitization is a tissue damage response whereby sensory
neurons near damaged tissue enhance their responsiveness to external stimuli. This …

One approach to develop successful pain therapies is the modulation of dysfunctional ion
channels that contribute to the detection of thermal, mechanical and chemical painful stimuli …

The transient receptor potential ankyrin 1 (TRPA1) ion channel is expressed on nociceptive
primary afferent neurons. On the proximal nerve ending within the spinal dorsal horn …

Transient receptor potential ion channels (TRPs) expressed in the periphery sense and
electrically transduce noxious stimuli to transmit the signals to the brain. Many natural and …

Hypersensitivity to thermal and mechanical stimuli can occur in painful pulpitis. To explore
the neuro-anatomical basis of heat and mechanical sensitivity, we evaluated expression of …

Transient receptor potential melastatin 8 (TRPM8) is a nonselective cation channel that is
thermoresponsive to cool to cold temperatures (8− 28° C) and also may be activated by …