Children differ from adults in their response to drugs. While this may be the result of changes
in dose exposure (pharmacokinetics [PK]) and/or exposure response (pharmacodynamics …

Pharmacokinetic (PK) and pharmacodynamic (PD) modeling has elucidated aspects of
developmental pharmacology of value to the anesthetic community. The increasing …

UDP-glucuronosyltransferases (UGTs) are critical for the metabolism and clearance of
drugs, chemicals, and hormones. The development of UGT1A1 and 1A6 was studied in 50 …

Providing safe and effective drug therapy to neonates requires knowledge of the impact of
development on the pharmacokinetics and pharmacodynamics of drugs. Although …

A physiologically based pharmacokinetic (PBPK) model was developed for bisphenol A
(BPA) in adult rhesus monkeys using intravenous (iv) and oral bolus doses of 100μgd6 …

Introduction: There are profound changes that take place in drug metabolism enzymes
during fetal and postnatal development. These changes may significantly impact drug …

Purpose A framework for the evaluation of paediatric population models is proposed and
applied to two different paediatric population pharmacokinetic models for morphine. One …

Abstract Background and Objective Model validation procedures are crucial when models
are to be used to develop new dosing algorithms. In this study, the predictive performance of …

Despite profound differences in response between children and adults, and between
children of different ages, drugs are still empirically dosed in mg/kg in children. Since …

Importance of the field: In recent years, interest in paediatric pharmacokinetics has grown.
Even though pharmacokinetic and pharmacodynamic relations determine together the …