Astrocytes are one of the major glial cell types that maintain homeostasis in the undamaged
CNS. After injury and disease, astrocytes become reactive and prevent regeneration; …

Astrocytes are the most abundant cell population within the CNS of mammals. Their glial
role is perfectly performed in the healthy CNS as they support functions of neurons. The …

Healthy brain aging and cognitive function are promoted by exercise. The benefits of
exercise are attributed to several mechanisms, many which highlight its neuroprotective role …

Tissue inhibitor of metalloproteinase-1 (TIMP-1) is an extracellular protein and endogenous
regulator of matrix metalloproteinases (MMPs) secreted by astrocytes in response to CNS …

Basic helix-loop-helix transcription factors Olig1 and Olig2 critically regulate oligodendrocyte
development. Initially identified as a downstream effector of Olig1, an oligodendrocyte …

Corticosteroids (CS) are effective in the treatment of many brain disorders, such as multiple
sclerosis (MS) or traumatic brain injury. This has been scrutinised in different experimental …

Over a century ago, hyperplasia and hypertrophy of astrocytes was noted as a
histopathological hallmark of multiple sclerosis and was hypothesized to play an important …

Our group intended to uncover histopathological and molecular changes within three
different brain regions in cuprizone-treated animals. The CC and the cerebral cortex are well …

Inflammatory responses have now been associated with many chronic neurodegenerative
conditions (eg, Multiple sclerosis, Alzheimer disease, Amyotrophic lateral sclerosis and …

Multiple sclerosis appears to be a self-programmed demyelination that alternates with
repeated episodes of often partial remyelination of the axon within a milieu of an expanding …