Current issues with acetaminophen hepatotoxicity—a clinically relevant model to test the efficacy of natural products
H Jaeschke, MR McGill, CD Williams… - Life sciences, 2011 - Elsevier
There is a significant need to evaluate the therapeutic potential of natural products and other
compounds purported to be hepatoprotective. Acetaminophen-induced liver injury …
compounds purported to be hepatoprotective. Acetaminophen-induced liver injury …
[PDF][PDF] HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity
MR McGill, HM Yan, A Ramachandran, GJ Murray… - …, 2011 - Wiley Online Library
Acetaminophen (APAP) overdose is the leading cause of acute liver failure in Western
countries. In the last four decades much progress has been made in our understanding of …
countries. In the last four decades much progress has been made in our understanding of …
The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen …
A Ramachandran, M Lebofsky, SA Weinman… - Toxicology and applied …, 2011 - Elsevier
Acetaminophen (APAP) hepatotoxicity is the most frequent cause of acute liver failure in
many countries. The mechanism of cell death is initiated by formation of a reactive …
many countries. The mechanism of cell death is initiated by formation of a reactive …
Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury
A Ramachandran, M Lebofsky, CP Baines… - Free radical …, 2011 - Taylor & Francis
Acetaminophen (APAP) hepatotoxicity is the main cause of acute liver failure in humans.
Although mitochondrial oxidant stress and induction of the mitochondrial permeability …
Although mitochondrial oxidant stress and induction of the mitochondrial permeability …
Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury
CD Williams, DJ Antoine, PJ Shaw, C Benson… - Toxicology and applied …, 2011 - Elsevier
Acetaminophen (APAP) overdose is the leading cause of acute liver failure in the US and
UK. Recent studies implied that APAP-induced injury is partially mediated by interleukin-1β …
UK. Recent studies implied that APAP-induced injury is partially mediated by interleukin-1β …
Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase
R Agarwal, LA MacMillan-Crow, TM Rafferty… - … of Pharmacology and …, 2011 - ASPET
In overdose the analgesic/antipyretic acetaminophen (APAP) is hepatotoxic. Toxicity is
mediated by initial hepatic metabolism to N-acetyl-p-benzoquinone imine (NAPQI). After low …
mediated by initial hepatic metabolism to N-acetyl-p-benzoquinone imine (NAPQI). After low …
Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity
ML Bajt, A Ramachandran, HM Yan… - Toxicological …, 2011 - academic.oup.com
Acetaminophen (APAP) overdose causes liver injury in humans and mice. DNA
fragmentation is a hallmark of APAP-induced cell death, and nuclear translocation of …
fragmentation is a hallmark of APAP-induced cell death, and nuclear translocation of …
Application of toxicogenomics in hepatic systems toxicology for risk assessment: acetaminophen as a case study
AS Kienhuis, JGM Bessems, JLA Pennings… - Toxicology and Applied …, 2011 - Elsevier
Hepatic systems toxicology is the integrative analysis of toxicogenomic technologies, eg,
transcriptomics, proteomics, and metabolomics, in combination with traditional toxicology …
transcriptomics, proteomics, and metabolomics, in combination with traditional toxicology …
Modulation of Bax/Bcl-2 and caspases by probiotics during acetaminophen induced apoptosis in primary hepatocytes
Oxidative stress is an important factor in drug induced hepatotoxicity and antioxidants from
natural sources have potential to ameliorate it. The present study was aimed to investigate …
natural sources have potential to ameliorate it. The present study was aimed to investigate …
Understanding lactic acidosis in paracetamol (acetaminophen) poisoning
AD Shah, DM Wood, PI Dargan - British journal of clinical …, 2011 - Wiley Online Library
Paracetamol (acetaminophen) is one of the most commonly taken drugs in overdose in
many areas of the world, and the most common cause of acute liver failure in both the UK …
many areas of the world, and the most common cause of acute liver failure in both the UK …