Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
P Martínez, MA Blasco - Nature Reviews Cancer, 2011 - nature.com
Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are
progressively lost with each round of cell division. Telomere protection requires a minimal …
progressively lost with each round of cell division. Telomere protection requires a minimal …
Combined toxic exposures and human health: biomarkers of exposure and effect
I Silins, J Högberg - International journal of environmental research and …, 2011 - mdpi.com
Procedures for risk assessment of chemical mixtures, combined and cumulative exposures
are under development, but the scientific database needs considerable expansion. In …
are under development, but the scientific database needs considerable expansion. In …
The telomerase activator TA‐65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence
Here, we show that a small‐molecule activator of telomerase (TA‐65) purified from the root
of Astragalus membranaceus is capable of increasing average telomere length and …
of Astragalus membranaceus is capable of increasing average telomere length and …
A germline variant in the TP53 polyadenylation signal confers cancer susceptibility
To identify new risk variants for cutaneous basal cell carcinoma, we performed a genome-
wide association study of 16 million SNPs identified through whole-genome sequencing of …
wide association study of 16 million SNPs identified through whole-genome sequencing of …
Lung cancer risk prediction: prostate, lung, colorectal and ovarian cancer screening trial models and validation
CM Tammemagi, PF Pinsky… - Journal of the …, 2011 - academic.oup.com
Introduction Identification of individuals at high risk for lung cancer should be of value to
individuals, patients, clinicians, and researchers. Existing prediction models have only …
individuals, patients, clinicians, and researchers. Existing prediction models have only …
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study
Z Kote-Jarai, AAA Olama, GG Giles, G Severi… - Nature …, 2011 - nature.com
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed
countries. We conducted a multi-stage genome-wide association study for PrCa and …
countries. We conducted a multi-stage genome-wide association study for PrCa and …
Genome-wide association study identifies three new melanoma susceptibility loci
We report a genome-wide association study for melanoma that was conducted by the
GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and …
GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and …
Genetics of lung-cancer susceptibility
Lung cancer is the most common form of cancer death worldwide. Although reduction of
tobacco consumption remains the most appropriate strategy to reduce lung-cancer burden …
tobacco consumption remains the most appropriate strategy to reduce lung-cancer burden …
[PDF][PDF] Constitutional telomerase mutations are genetic risk factors for cirrhosis
Some patients with liver disease progress to cirrhosis, but the risk factors for cirrhosis
development are unknown. Dyskeratosis congenita, an inherited bone marrow failure …
development are unknown. Dyskeratosis congenita, an inherited bone marrow failure …
Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans
GWAS of prostate cancer have been remarkably successful in revealing common genetic
variants and novel biological pathways that are linked with its etiology. A more complete …
variants and novel biological pathways that are linked with its etiology. A more complete …