Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins

P Martínez, MA Blasco - Nature Reviews Cancer, 2011 - nature.com
Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are
progressively lost with each round of cell division. Telomere protection requires a minimal …

Combined toxic exposures and human health: biomarkers of exposure and effect

I Silins, J Högberg - International journal of environmental research and …, 2011 - mdpi.com
Procedures for risk assessment of chemical mixtures, combined and cumulative exposures
are under development, but the scientific database needs considerable expansion. In …

The telomerase activator TA‐65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence

BB de Jesus, K Schneeberger, E Vera, A Tejera… - Aging cell, 2011 - Wiley Online Library
Here, we show that a small‐molecule activator of telomerase (TA‐65) purified from the root
of Astragalus membranaceus is capable of increasing average telomere length and …

A germline variant in the TP53 polyadenylation signal confers cancer susceptibility

SN Stacey, P Sulem, A Jonasdottir, G Masson… - Nature …, 2011 - nature.com
To identify new risk variants for cutaneous basal cell carcinoma, we performed a genome-
wide association study of 16 million SNPs identified through whole-genome sequencing of …

Lung cancer risk prediction: prostate, lung, colorectal and ovarian cancer screening trial models and validation

CM Tammemagi, PF Pinsky… - Journal of the …, 2011 - academic.oup.com
Introduction Identification of individuals at high risk for lung cancer should be of value to
individuals, patients, clinicians, and researchers. Existing prediction models have only …

Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

Z Kote-Jarai, AAA Olama, GG Giles, G Severi… - Nature …, 2011 - nature.com
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed
countries. We conducted a multi-stage genome-wide association study for PrCa and …

Genome-wide association study identifies three new melanoma susceptibility loci

JH Barrett, MM Iles, M Harland, JC Taylor, JF Aitken… - Nature …, 2011 - nature.com
We report a genome-wide association study for melanoma that was conducted by the
GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and …

Genetics of lung-cancer susceptibility

P Brennan, P Hainaut, P Boffetta - The lancet oncology, 2011 - thelancet.com
Lung cancer is the most common form of cancer death worldwide. Although reduction of
tobacco consumption remains the most appropriate strategy to reduce lung-cancer burden …

[PDF][PDF] Constitutional telomerase mutations are genetic risk factors for cirrhosis

RT Calado, J Brudno, P Mehta, JJ Kovacs, C Wu… - …, 2011 - Wiley Online Library
Some patients with liver disease progress to cirrhosis, but the risk factors for cirrhosis
development are unknown. Dyskeratosis congenita, an inherited bone marrow failure …

Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans

CA Haiman, GK Chen, WJ Blot, SS Strom… - PLoS …, 2011 - journals.plos.org
GWAS of prostate cancer have been remarkably successful in revealing common genetic
variants and novel biological pathways that are linked with its etiology. A more complete …