Prompt and efficient clearance of apoptotic cells is necessary to prevent secondary necrosis
of dying cells and to avoid immune responses to autoantigens. Recent studies have shed …

Evolving studies in models of transplant rejection, inflammatory bowel disease, and cancer,
among others, have implicated purinergic signaling in clinical manifestations of vascular …

The mechanisms of chronic infections caused by opportunistic pathogens are of keen
interest to both researchers and health professionals globally. Typically, chronic infectious …

Non-invasive in vivo imaging of drug distribution enables real-time monitoring and
prediction of therapeutic responses to treatment. We have developed a thermosensitive …

The ectonucleotidases CD39 and CD73 degrade immune stimulatory ATP to adenosine that
inhibits T and NK cell responses via the A 2A adenosine receptor (ADORA2A). This …

Introduction 3. Is extracellular ATP present at inflammatory foci? 4. Does reduced
extracellular ATP affect inflammation? 5. Does P2 receptor stimulation influence …

Extracellular adenosine triphosphate (ATP) is known to boost immune responses in the
tumor microenvironment but might also contribute directly to cancer cell death …

Lipids in the cytoplasm membrane fulfill numerous functions. We focus on how lipid
asymmetry is generated and its physiological and pathophysiological mission. The role of …

Histone deacetylase inhibitors (HDACi) have been successfully used as monotherapies for
the treatment of hematological malignancies; however, the single agent effects of HDACi …

Plant polysaccharides present an interesting potential as immunomodulators, particularly in
the induction of antitumoral responses, principally because of their molecular complexity …