Proteases as therapeutics
CS Craik, MJ Page, EL Madison - Biochemical Journal, 2011 - portlandpress.com
Proteases are an expanding class of drugs that hold great promise. The US FDA (Food and
Drug Administration) has approved 12 protease therapies, and a number of next generation …
Drug Administration) has approved 12 protease therapies, and a number of next generation …
The effect of inflammation on coagulation and vice versa
T van der Poll, JD de Boer, M Levi - Current opinion in infectious …, 2011 - journals.lww.com
Recent data provide new insights into how inflammation impacts on coagulation and vice
versa, identifying crucial roles for PARs. This knowledge may assist in designing novel …
versa, identifying crucial roles for PARs. This knowledge may assist in designing novel …
[HTML][HTML] Activated protein C protects against myocardial ischemic/reperfusion injury through AMP‐activated protein kinase signaling
J Wang, L Yang, AR Rezaie, J Li - Journal of Thrombosis and Haemostasis, 2011 - Elsevier
Summary Background: Activated protein C (APC) is a vitamin K‐dependent plasma serine
protease that down‐regulates clotting and inflammatory pathways. It is known that APC …
protease that down‐regulates clotting and inflammatory pathways. It is known that APC …
[HTML][HTML] The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors
J Disse, HH Petersen, KS Larsen, E Persson… - Journal of biological …, 2011 - ASBMB
Protease-activated receptor (PAR) signaling is closely linked to the cellular activation of the
pro-and anticoagulant pathways. The endothelial protein C receptor (EPCR) is crucial for …
pro-and anticoagulant pathways. The endothelial protein C receptor (EPCR) is crucial for …
Multiple receptor-mediated functions of activated protein C
H Weiler - Hämostaseologie, 2011 - thieme-connect.com
The central effector protease of the protein C pathway, activated protein C (APC), interacts
with the endothelial cell protein C receptor, with protease activated receptors (PAR), the …
with the endothelial cell protein C receptor, with protease activated receptors (PAR), the …
Inhibition of guanylyl cyclase restores neutrophil migration and maintains bactericidal activity increasing survival in sepsis
Sepsis results from an overwhelming response to infection and is a major contributor to
death in intensive care units worldwide. In recent years, we and others have shown that …
death in intensive care units worldwide. In recent years, we and others have shown that …
[HTML][HTML] Protein C concentrate controls leukocyte recruitment during inflammation and improves survival during endotoxemia after efficient in vivo activation
D Frommhold, J Tschada, N Braach… - The American Journal of …, 2011 - Elsevier
Anti-inflammatory properties of protein C (PC) concentrate are poorly studied compared to
activated protein C, although PC is suggested to be safer in clinical use. We investigated …
activated protein C, although PC is suggested to be safer in clinical use. We investigated …
Effects of long-term administration of recombinant human protein C in xenografted primates
P Simioni, M Boldrin, S Gavasso, M Seveso… - …, 2011 - journals.lww.com
Background. The role potential of recombinant human activated protein C (rhaPC), a
recently developed molecule with anticoagulant and antiinflammatory properties, in …
recently developed molecule with anticoagulant and antiinflammatory properties, in …
[HTML][HTML] La protéine C activée-Une protéine à l'interface de l'inflammation et de la coagulation
D Borgel, A Vieillard-Baron - médecine/sciences, 2011 - medecinesciences.org
Le sepsis est défini comme une réponse systémique de l'organisme à une infection. Au plan
physiopathologique, la réponse de l'hôte à l'infection est caractérisée, d'une part par une …
physiopathologique, la réponse de l'hôte à l'infection est caractérisée, d'une part par une …