The regulatory function of SPARC in vascular biology
LB Rivera, AD Bradshaw, RA Brekken - Cellular and Molecular Life …, 2011 - Springer
SPARC is a matricellular protein, able to modulate cell/ECM interactions and influence cell
responses to growth factors, and therefore is particularly attuned to contribute to …
responses to growth factors, and therefore is particularly attuned to contribute to …
[HTML][HTML] Molecular signature of epithelial-mesenchymal transition (EMT) in human prostate cancer bone metastasis
S Sethi, J Macoska, W Chen… - American journal of …, 2011 - ncbi.nlm.nih.gov
Prostate cancer (PCa) has a predilection to metastasize to bone. Before metastasis can
occur there is transition of the sessile epithelial cancer cells to become motile and invasive …
occur there is transition of the sessile epithelial cancer cells to become motile and invasive …
Vascular endothelial growth factor A (VEGF-A) induces endothelial and cancer cell migration through direct binding to integrin α9β1: identification of a specific α9β1 …
Integrin α9β1 mediates accelerated cell adhesion and migration through interactions with a
number of diverse extracellular ligands. We have shown previously that it directly binds the …
number of diverse extracellular ligands. We have shown previously that it directly binds the …
SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival
N Fenouille, A Puissant, M Tichet, G Zimniak, P Abbe… - Oncogene, 2011 - nature.com
Abstract Aberrant expression of Secreted Protein Acidic and Rich in Cysteine
(SPARC)/osteonectin has been associated with an invasive tumor cell phenotype and poor …
(SPARC)/osteonectin has been associated with an invasive tumor cell phenotype and poor …
Intravenous injection of leconotide, an omega conotoxin: synergistic antihyperalgesic effects with morphine in a rat model of bone cancer pain
A Kolosov, L Aurini, ED Williams, I Cooke… - Pain …, 2011 - academic.oup.com
Abstract Objective. Leconotide (CVID, AM336, CNSB004) is an omega conopeptide similar
to ziconotide, which blocks voltage sensitive calcium channels. However, unlike ziconotide …
to ziconotide, which blocks voltage sensitive calcium channels. However, unlike ziconotide …
Augmented osteolysis in SPARC-deficient mice with bone-residing prostate cancer
NP McCabe, BA Kerr, M Madajka, A Vasanji… - Neoplasia, 2011 - Elsevier
Prostate cancer preferentially metastasizes to bone, which is rich in structural and
matricellular proteins capable of altering prostate cancer progression. This study explores …
matricellular proteins capable of altering prostate cancer progression. This study explores …
人参皂苷Rg3 联合紫杉醇抗胃癌转移的作用及机制研究
袁国荣， 叶再元 - 中华中医药学刊, 2011 - cqvip.com
目的: 探讨人参皂苷Rg3 联合紫杉醇协同抗胃癌转移的作用及机制. 方法: 将人胃癌BGC—823
细胞裸鼠移植瘤动物模型, 随机分为四组(每组10 只): 人参皂苷Rg3 组[GS-Rg3: 10mg/(kg. d) …
细胞裸鼠移植瘤动物模型, 随机分为四组(每组10 只): 人参皂苷Rg3 组[GS-Rg3: 10mg/(kg. d) …
A phase 1, multicenter, open-label study of the safety of two dose levels of a human monoclonal antibody to human αv integrins, intetumumab, in combination with …
FM Chu, J Picus, PM Fracasso, R Dreicer, Z Lang… - Investigational new …, 2011 - Springer
Purpose We evaluated the safety and efficacy of intetumumab in combination with docetaxel
in patients with castrate-resistant metastatic prostate cancer. Patients and methods In this …
in patients with castrate-resistant metastatic prostate cancer. Patients and methods In this …
Active sonic hedgehog signaling between androgen independent human prostate cancer cells and normal/benign but not cancer‐associated prostate stromal cells
K Shigemura, WC Huang, X Li, HE Zhau, G Zhu… - The …, 2011 - Wiley Online Library
BACKGROUND Sonic hedgehog (Shh) signaling plays a pivotal role in stromal–epithelial
interaction during normal development but its role in tumor–stromal interaction during …
interaction during normal development but its role in tumor–stromal interaction during …
Knockdown of Secreted Protein Acidic and Rich in Cysteine (SPARC) Expression Diminishes Radiosensitivity of Glioma Cells
H Liu, H Zhang, X Jiang, Y Ma, Y Xu… - Cancer Biotherapy and …, 2011 - liebertpub.com
Secreted protein acidic and rich in cysteine (SPARC) has been shown to play an important
role in the promotion of glioma. In this study, we investigated the effects of downregulated …
role in the promotion of glioma. In this study, we investigated the effects of downregulated …