Melanoma-associated antigen genes–an update
M Sang, L Wang, C Ding, X Zhou, B Wang, L Wang… - Cancer letters, 2011 - Elsevier
To date, dozens of melanoma-associated antigens (MAGE) have been identified. Based on
the differences in tissue-specific gene expression and gene structure, the MAGE family has …
the differences in tissue-specific gene expression and gene structure, the MAGE family has …
Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery
Z Zhang, S Tongchusak, Y Mizukami, YJ Kang, T Ioji… - Biomaterials, 2011 - Elsevier
Nanotechnology-based antigen delivery has been developing as a vaccine strategy due to
its dose-sparing and prolonged antigen presentation features. In the current study, we …
its dose-sparing and prolonged antigen presentation features. In the current study, we …
A TCR targeting the HLA-A* 0201–restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer
N Chinnasamy, JA Wargo, Z Yu, M Rao… - The Journal of …, 2011 - journals.aai.org
Adoptive immunotherapy using TCR-engineered PBLs against melanocyte differentiation
Ags mediates objective tumor regression but is associated with on-target toxicity. To avoid …
Ags mediates objective tumor regression but is associated with on-target toxicity. To avoid …
[HTML][HTML] T-cell receptor gene therapy: critical parameters for clinical success
C Linnemann, TNM Schumacher, GM Bendle - Journal of investigative …, 2011 - Elsevier
T-cell receptor (TCR) gene therapy aims to induce immune reactivity against tumors by
introducing genes encoding a tumor-reactive TCR into patient T cells. This approach has …
introducing genes encoding a tumor-reactive TCR into patient T cells. This approach has …
Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen
S Thomas, SA Xue, CRM Bangham… - Blood, The Journal …, 2011 - ashpublications.org
We have tested whether affinity-matured TCRs that retain peptide specificity improve the
ability of primary human CD8+ T cells to mount antigen-specific responses. We found that …
ability of primary human CD8+ T cells to mount antigen-specific responses. We found that …
[HTML][HTML] Repeated PR1 and WT1 peptide vaccination in Montanide-adjuvant fails to induce sustained high-avidity, epitope-specific CD8+ T cells in myeloid …
K Rezvani, ASM Yong, S Mielke, B Jafarpour… - …, 2011 - ncbi.nlm.nih.gov
Repeated PR1 and WT1 peptide vaccination in Montanide-adjuvant fails to induce
sustained high-avidity, epitope-specific CD8+ T cells in myeloid malignancies - PMC Back …
sustained high-avidity, epitope-specific CD8+ T cells in myeloid malignancies - PMC Back …
Antitumor activity mediated by CpG: the route of administration is critical
Abstract Unmethylated CpG oligodeoxynucleotides (CpG) are synthetic toll-like receptor 9
agonists that activate innate immune cells and which have been tested as an immune …
agonists that activate innate immune cells and which have been tested as an immune …
Adjuvant combination and antigen targeting as a strategy to induce polyfunctional and high-avidity T-cell responses against poorly immunogenic tumors
F Aranda, D Llopiz, N Díaz-Valdés, JI Riezu-Boj… - Cancer research, 2011 - AACR
Low antigen expression and an absence of coimmunostimulatory signals may be partly
responsible for the low immunogenicity of many tumors. It may be possible to overcome this …
responsible for the low immunogenicity of many tumors. It may be possible to overcome this …
Mucosal immunity and HIV-1 infection: applications for mucosal AIDS vaccine development
IM Belyakov, JD Ahlers - Mucosal Vaccines: Modern Concepts, Strategies …, 2011 - Springer
Natural transmission of human immunodeficiency virus type 1 (HIV-1) occurs through
gastrointestinal and vaginal mucosa. These mucosal tissues are major reservoirs for initial …
gastrointestinal and vaginal mucosa. These mucosal tissues are major reservoirs for initial …
[HTML][HTML] The potency of allospecific Tregs cells appears to correlate with T cell receptor functional avidity
JYS Tsang, K Ratnasothy, D Li, Y Chen… - American Journal of …, 2011 - Elsevier
CD4+ CD25+ regulatory T cells (T reg cells) are an attractive adoptive cell therapy in
mediating transplantation tolerance. T-cell receptor (TcR) activation is critical for T reg …
mediating transplantation tolerance. T-cell receptor (TcR) activation is critical for T reg …