Vascular calcification increasingly afflicts our aging, dysmetabolic population. Once
considered only a passive process of dead and dying cells, vascular calcification has now …

Abstract Background: Although Dickkopf‐1 (DKK1) is known to be a negative regulator of the
Wnt/β‐catenin pathway, it has been recently found to be upregulated in cancers. Aims: We …

The physiological role of Dickkopf‐1 (Dkk1) during postnatal bone growth in rodents and in
adult rodents was examined utilizing an antibody to Dkk1 (Dkk1‐Ab) that blocked Dkk1 …

BACKGROUND & AIMS: Dkk1 is a secreted antagonist of the Wnt/β-catenin signaling
pathway. It is induced by inflammatory cytokines during colitis and exacerbates tissue …

Introduction 3. The cadherin: catenin complex 3.1. The cadherin structure 3.. 2. The beta-
catenin Wnt pathway 3.3. Wnt pathway inhibitors 4. Role of cadherin: catenin complex in …

OBJECTIVES: Previous data suggest that Dickkopf-1 (Dkk-1), an inhibitor of the canonical/β-
catenin cascade of the Wnt pathway, is upregulated in carotid atherosclerosis and acute …

DKK1 modulates Wnt signaling, which is involved in the atherosclerosis. However, no data
exist regarding the usefulness of measuring serum DKK1 concentration in predicting …

Objective—The goal of this study was to assess the activity of β-catenin/T-cell-specific
transcription factor (TCF) signaling in atherosclerosis development and its regulation of …

The critical role of the Wnt pathway inhibition in sustaining the onset of bone lesions has
been demonstrated in a variety of bone diseases and tumors, and it has been associated …

The major biomarker for rectal cancer is the pathologic development of the tumor. In our
study, we identified Dikkopf-1 (DKK1) as a novel biomarker and a therapeutic target for …