The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease
Regular exercise reduces the risk of chronic metabolic and cardiorespiratory diseases, in
part because exercise exerts anti-inflammatory effects. However, these effects are also likely …
part because exercise exerts anti-inflammatory effects. However, these effects are also likely …
Hyaluronan as an immune regulator in human diseases
Accumulation and turnover of extracellular matrix components are the hallmarks of tissue
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …
[HTML][HTML] The structural biology of Toll-like receptors
I Botos, DM Segal, DR Davies - Structure, 2011 - cell.com
The membrane-bound Toll-like receptors (TLRs) trigger innate immune responses after
recognition of a wide variety of pathogen-derived compounds. Despite the wide range of …
recognition of a wide variety of pathogen-derived compounds. Despite the wide range of …
LPS-induced cytokine production in human monocytes and macrophages
Lipopolysaccharide (LPS) from Gram-negative bacteria is one of the most potent innate
immune-activating stimuli known. Here we review the current understanding of LPS effects …
immune-activating stimuli known. Here we review the current understanding of LPS effects …
Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential
The discovery of mammalian TLRs (Toll-like receptors), first identified in 1997 based on their
homology with Drosophila Toll, greatly altered our understanding of how the innate immune …
homology with Drosophila Toll, greatly altered our understanding of how the innate immune …
Toll-like receptors in bony fish: from genomics to function
Y Palti - Developmental & Comparative Immunology, 2011 - Elsevier
Receptors that recognize conserved pathogen molecules are the first line of cellular innate
immunity defense. Toll-like receptors (TLRs) are the best understood of the innate immune …
immunity defense. Toll-like receptors (TLRs) are the best understood of the innate immune …
MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases
R Dai, SA Ahmed - Translational Research, 2011 - Elsevier
MicroRNAs (miRNAs) are newly discovered, small, noncoding ribonucleic acids (RNAs) that
play critical roles in the regulation of host genome expression at the posttranscriptional level …
play critical roles in the regulation of host genome expression at the posttranscriptional level …
[HTML][HTML] TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes
K Yamasaki, K Kanada, DT Macleod… - Journal of Investigative …, 2011 - Elsevier
A diverse environment challenges skin to maintain temperature, hydration, and electrolyte
balance while also maintaining normal immunological function. Rosacea is a common skin …
balance while also maintaining normal immunological function. Rosacea is a common skin …
Immunoglobulin responses at the mucosal interface
Mucosal surfaces are colonized by large communities of commensal bacteria and represent
the primary site of entry for pathogenic agents. To prevent microbial intrusion, mucosal B …
the primary site of entry for pathogenic agents. To prevent microbial intrusion, mucosal B …
In Vitro and in Vivo mRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles
X Su, J Fricke, DG Kavanagh… - Molecular pharmaceutics, 2011 - ACS Publications
Biodegradable core− shell structured nanoparticles with a poly (β-amino ester)(PBAE) core
enveloped by a phospholipid bilayer shell were developed for in vivo mRNA delivery with a …
enveloped by a phospholipid bilayer shell were developed for in vivo mRNA delivery with a …