Saliva: a potential media for disease diagnostics and monitoring

J Liu, Y Duan - Oral oncology, 2012 - Elsevier
Within the past 10years, the use of saliva as a diagnostic tool has gained considerable
attention and become a well-accepted method. As a diagnostic fluid, saliva offers superiority …

Salivary biomarker development using genomic, proteomic and metabolomic approaches

NJ Bonne, DTW Wong - Genome medicine, 2012 - Springer
The use of saliva as a diagnostic sample provides a non-invasive, cost-efficient method of
sample collection for disease screening without the need for highly trained professionals …

[HTML][HTML] Salivary and serum interleukin 1 beta, interleukin 6 and tumor necrosis factor alpha in patients with leukoplakia and oral cancer

V Brailo, V Vucicevic-Boras, J Lukac… - … oral, patología oral y …, 2012 - ncbi.nlm.nih.gov
Objectives: The aim of study was to compare salivary and serum concentrations of
interleukin 1 beta (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) in …

Control of cytokine mRNA expression by RNA-binding proteins and microRNAs

V Palanisamy, A Jakymiw… - Journal of dental …, 2012 - journals.sagepub.com
Cytokines are critical mediators of inflammation and host defenses. Regulation of cytokines
can occur at various stages of gene expression, including transcription, mRNA export, and …

Secretion of IL-6 and IL-8 from lysophosphatidic acid-stimulated oral squamous cell carcinoma promotes osteoclastogenesis and bone resorption

YS Hwang, SK Lee, KK Park, WY Chung - Oral oncology, 2012 - Elsevier
Lysophosphatidic acid (LPA) is a bioactive lipid with a growth factor-like activity on a large
range of cell types. Several pieces of evidence raise the possibility that LPA may play an …

Salivary protein and solCD44 levels as a potential screening tool for early detection of head and neck squamous cell carcinoma

EJ Franzmann, EP Reategui, LHM Pereira… - Head & …, 2012 - Wiley Online Library
Background Head and neck squamous cell carcinoma (HNSCC) is a devastating disease
usually diagnosed at a late stage when cure rates are 40%. We examined a simple and …

(−)-Epigallocatechin gallate induces Fas/CD95-mediated apoptosis through inhibiting constitutive and IL-6-induced JAK/STAT3 signaling in head and neck squamous …

HY Lin, SC Hou, SC Chen, MC Kao… - Journal of agricultural …, 2012 - ACS Publications
In this study, we examined the effects of several plant-derived natural compounds on head
and neck squamous cell carcinoma (HNSCC) cells. The results revealed that (−) …

The human salivary RNA transcriptome revealed by massively parallel sequencing

N Spielmann, D Ilsley, J Gu, K Lea… - Clinical …, 2012 - academic.oup.com
BACKGROUND Evaluation of the salivary transcriptome is an emerging diagnostic
technology with discriminatory power for disease detection. This study explored massively …

[HTML][HTML] Human defensins: potential tools for clinical applications

J Winter, M Wenghoefer - Polymers, 2012 - mdpi.com
As components of the innate immune system, antimicrobial peptides in the form of human
defensins play an important role in host defense by serving as the epithelial layer's …

Gender difference in the prognostic role of interleukin 6 in oral squamous cell carcinoma

CJ Chen, WW Sung, YM Lin, MK Chen, CH Lee… - PLoS …, 2012 - journals.plos.org
Background Interleukin 6 (IL6) plays an important role in immunoregulation and
tumorigenesis in human cancers. Oral squamous cell carcinoma (OSCC) is a malignant …