The hypothesis that differences in gene regulation have an important role in speciation and
adaptation is more than 40 years old. With the advent of new sequencing technologies, we …

Genome-wide association studies and comparative genomics have established major loci
and specific polymorphisms affecting human skin, hair and eye color. Environmental …

Crop domestications are long-term selection experiments that have greatly advanced
human civilization. The domestication of cultivated rice (Oryza sativa L.) ranks as one of the …

Human-disease etiology can be better understood with phase information about diploid
sequences. We present a method for estimating haplotypes, using genotype data from …

Genome-sequencing studies indicate that all humans carry many genetic variants predicted
to cause loss of function (LoF) of protein-coding genes, suggesting unexpected redundancy …

Genome-wide patterns of homozygosity runs and their variation across individuals provide a
valuable and often untapped resource for studying human genetic diversity and evolutionary …

Evolving resistance to artemisinin-based compounds threatens to derail attempts to control
malaria. Resistance has been confirmed in western Cambodia and has recently emerged in …

Strong signatures of positive selection at newly arising genetic variants are well documented
in humans,,,,,,,, but this form of selection may not be widespread in recent human evolution …

Background Identification of genomic regions that have been targets of selection for
phenotypic traits is one of the most important and challenging areas of research in animal …

Theory and empirical data from a variety of disciplines strongly imply that recent human
history involves extensive gene-culture coevolution, much of it as a direct result of human …