Asthma is a chronic airway disease characterized by paroxysmal airflow obstruction evoked
by irritative stimuli on a background of allergic lung inflammation. Currently, there is no cure …

The methodology for EPOS2012 has been the same as for the other two productions.
Leaders in the field were invited to critically appraise the literature and write a report on a …

Systemic autoimmune and rheumatic diseases (SAIRDs) are thought to develop due to the
failure of autoimmune regulation and tolerance. Current therapies, such as biologics, have …

In dogs, there are several idiopathic meningoencephalitides, such as necrotizing
meningoencephalitis (NME), necrotizing leukoencephalitis (NLE), and granulomatous …

Rationale Upregulation of glucocorticoid receptor β (GRβ) has been implicated in steroid
resistance in severe asthma, although previous studies are conflicting. GRβ has been …

There is concern that P-glycoprotein mediated efflux contributes to steroid resistance.
Therefore, this study examined bidirectional corticosteroid transport and induction …

Background Although combined oral and nasal steroid therapy is widely used in nasal
polyposis, a subset of patients show an unfavorable therapeutic outcome. This study aimed …

Bronchial asthma is a disease of multifactorial etiology. The natural variability of the DNA
sequence within the h-GR/NR3C1 gene affects both the conformation and the activity of …

Endogenous glucocorticoids are secreted by the hypothalamic-pituitary-adrenal (HPA) axis
in response to a wide range of stressors. Glucocorticoids exert significant downstream …

Background Asthma is a common chronic disease characterized by airway inflammation and
structural remodeling. Vascular endothelial growth factor (VEGF), a major regulator of …