Marketed drugs frequently perform worse in clinical practice than in the clinical trials on
which their approval is based. Many therapeutic compounds are ineffective for a large …

Despite the widespread importance of RING/U-box E3 ubiquitin ligases in ubiquitin (Ub)
signaling, the mechanism by which this class of enzymes facilitates Ub transfer remains …

Novel discoveries in molecular disease pathways within the cell, combined with increasing
information regarding protein binding partners has lead to a new approach in drug …

Sti1/Hop is a modular protein required for the transfer of client proteins from the Hsp70 to the
Hsp90 chaperone system in eukaryotes. It binds Hsp70 and Hsp90 simultaneously via TPR …

A key process underlying an innate immune response to pathogens or cellular stress is
activation of members of the NOD-like receptor family, such as NLRP3, to assemble caspase …

Abstract The WeNMR (http://www. wenmr. eu) project is a European Union funded
international effort to streamline and automate analysis of Nuclear Magnetic Resonance …

The small hydrophobic (SH) protein is encoded by the human respiratory syncytial virus. Its
absence leads to viral attenuation in the context of whole organisms, and it prevents …

Lamin A/C proteins are the major components of a thin proteinaceous filamentous
meshwork, the lamina, that underlies the inner nuclear membrane. A few specific mutations …

Eight different types of ubiquitin linkages are present in eukaryotic cells that regulate diverse
biological processes. Proteins that mediate specific assembly and disassembly of atypical …

The hydrophobin EAS from the fungus Neurospora crassa forms functional amyloid fibrils
called rodlets that facilitate spore formation and dispersal. Self-assembly of EAS into fibrillar …