B cells and antibodies account for the most prominent immunodiagnostic feature in patients
with multiple sclerosis (MS), namely oligoclonal bands. Furthermore, evidence is …

All multicellular organisms protect themselves against pathogens using sophisticated
immune defenses. Functionally interconnected humoral and cellular facilities maintain …

Multiple sclerosis (MS) is a chronic autoimmune, inflammatory neurological disease of the
central nervous system (CNS). 1, 2 MS attacks the myelinated axons in the CNS, destroying …

In multiple sclerosis (MS) pathogenic B cells likely act on both sides of the blood-brain
barrier (BBB). However, it is unclear whether antigen-experienced B cells are shared …

MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression. We compared
the expression of 1059 miRNAs in B lymphocytes from untreated and natalizumab treated …

Multiple sclerosis (MS) is a potentially disabling chronic autoimmune neurological disease
that mainly affects young adults. Our understanding of the pathophysiology of MS has …

Bacterial and viral infections have been shown to induce relapses and accelerate the
progression of multiple sclerosis (MS). Vaccination to prevent communicable disease in …

The pathogenic role for B cells in the context of relapsing remitting multiple sclerosis (MS) is
incompletely defined. Although classically considered a T cell-mediated disease, B cell …

Recent years have broadened the spectrum of therapeutic strategies and specific agents for
treatment of multiple sclerosis (MS). While immune-modulating drugs remain the first-line …

Multiple sclerosis is a potentially debilitating disease of the central nervous system. A
concerted program of research by many centers around the world has consistently …